Study of newly synthesized pyridine-pyrimidine-oxadiazole comprising molecules as antimicrobial agent
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
Substituted pyrimidine based 1,3,4-oxadiazoles were taken as lead moieties and merged it with heterocycles like pyridine and 1,3,4-thiadiazole to obtained more effective derivatives named N-(5-(6- methyl-2-oxo-4-(substitutedphenyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl)-2-((5-(2- (phenylthio)pyridin-3-yl)-1,3,4-thiadiazol-2-yl)amino)acetamide 1a-m. Synthesized compounds were confirmed by IR, NMR, Mass spectra and Elemental analysis, as well as their assessment for antimicrobial activities against different microbial species like S. aureusandS, pyogenes (Gram-positive bacteria), E. coli and P. aeruginosa (Gram-negative bacteria) and C. albicans, A.nigerand A. clavatus (fungi) using serial broth dilution method.
Authors and Affiliations
Patel NB and Sabirkhan S Pathan
Keywords
Related Articles
- EP ID EP33380
- DOI -
- Views 239
- Downloads 0
Terminalia bellerica leaf extracts induce apoptosis in Hep G2 cells and regulates cell cycle progression by inducing G2/M cell cycle arrest
The present study implicit the observation that leaf extracts of Terminalia bellerica have promising anticancer ingredients with IC50 of 5.65µg/ml. Phytochemical studies have revealed that Terminalia bellerica contains...
Formulation and evaluation of osmotic controlled release verapamil tablets
Controlled release tablets of verapamil based on osmotic technology was developed and evaluated. Verapamil half life2.8-7.4 Hrs, it is short acting drug, developed formulation provide the prolong controlled release for...
Design & characterization of candesartan Celexetil loaded solid lipid nanoparticles for effective management against CVS disorders
The present work aims to formulate solid lipid nanoparticles loaded with candesartan celexetil for the increase in the efficiency against cardio vascular disorders and increase the retention time to control the fluctua...
TRANSDERMAL DRUG DELIVERY SYSTEMS
Transdermal therapeutic systems have been designed to provide controlled continuous delivery of drugs via the skin to the systemic circulation. The relative impermeability of skin is well known, and this is associated...
Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs
Nanotechnology has gained a great interest due to the needs and applications of nanomaterials in many areas including agriculture, industry, medicine business and public health. The increase in the use of nanomaterials...