FORMULATION AND IN VITRO EVALUATION OF CEFIXIME MICROSPHERES PREPARED MULTIPLE EMULSION TECHNIQUE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 9
Abstract
The purpose of the research work was to prepare and evaluate the microspheres of cefixime as a model drug by multiple emulation method with gelatin as polymer in various proportions. A total of six formulations were prepared i.e. F1, F2, F3, F4, F5 and F6. The microspheres were evaluated for micromeritic properties, particle size, % yield, Drug content and Drug release. The size or average diameter of prepared microspheres was in between 4μm-16 μm. Cefixime release from these microspheres was sustained by various rations of gelatin. The formulation F2 and F5 showed consistent drug release for up to 8 h time period. Among all the formulations, F4 contains gelatin ratio (1:4) showed the reproducible results with best release profile and good surface morphology.
Authors and Affiliations
Kotta Kranthi Kumar*| Department of Pharmaceutics, S.K.U College of Pharmaceutica lsciences S.K.University, Anantapur, India, M. Sabareerh| Krishna Tejapharmacy College Tirupathi, India, Dmk Chakradhar| Shri Sai College of Pharmacy Gajapathinagaram, India
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