FORMULATION AND IN-VITRO EVALUATION OF FAST DISSOLVING TABLETS OF LACOSAMIDE USING NATURAL SUPER DISINTEGRANTS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
Fast dissolving tablets are those which disintegrates rapidly within the mouth and taken without consumption of water. The present work is concerned with the formulation and in-vitro evaluation of Lacosamide fast dissolving tablets. Lacosamide is a novel anti-epileptic drug used in the treatment of partial onset of seizures. The objective of this study was to improve the rapid onset of action of the drug. The fast dissolving tablets of Lacosamide were prepared using direct compression method by employing natural super- disintegrating agents like dehydrated banana powder (DBP) and Ocimum sanctum powder. Different concentrations of superdisintegrants were used in the formulations as 2%, 4%, 6%, and 8%. The prepared tablets were evaluated for pre-compression parameters like bulk density, tapped density, angle of repose, Hausner ratio, Carr's index, and were in the acceptable range. Post-compression parameters like hardness, friability, drug content, wetting time, water absorption ratio, disintegration time, and dissolution study were also evaluated. From the results obtained, it was found that tablet formulation with 8% concentration of Ocimum sanctum seed powder (F8) showed 98% of drug release at the end of 30 min and disintegration time was found to be 25 sec. Also, the hardness, friability, weight variation, and drug content of prepared tablets were found to be in the acceptable limits. The in-vitro release kinetics reveals that formulation (F8) follows first order kinetics.
Authors and Affiliations
C. Haranath et al.
Keywords
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- EP ID EP580658
- DOI 10.13040/IJPSR.0975-8232.10(6).2769-76
- Views 132
- Downloads 0
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