FORMULATION AND OPTIMIZATION OF RAFT FORMING CHEWABLE TABLET CONTAINING LAFUTIDINE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 3
Abstract
Lafutidine is a new histamine H2- receptor antagonist having biological half-life of 1.92 h. Due to its selective absorption from upper part of gastrointestinal tract the gastroretentive drug delivery is desired in order to enhance its bioavailability. The aim of research was to formulate chewable tablets of lafutidine along with raft forming agent, antacid and gas generating agent. Tablets were prepared by wet granulation method and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, and in vitro drug release. Various raft-forming agents were used in preliminary screening. A 32 full factorial design was used for optimization in present study. Amount of calcium carbonate and ratio of sodium alginate to pectin were used as independent variables while raft strength and acid neutralizations capacity were used as dependent variables. Batch F8 was selected as optimized formulation based on maximum raft strength and good acid neutralization capacity. Drug-excipients compatibility study showed no interaction between drug and excipients. Stability study of the optimized formulation showed that the tablets were stable at accelerated environmental conditions for 1 month. It was concluded that raft forming chewable tablets prepared using an optimum amount of sodium alginate, pectin and calcium carbonate could be an efficient dosage form in the treatment of gastro oesophageal reflux disease.
Authors and Affiliations
Dasharath M. Patel, Dimpal G. Patel, Chhagan N. Patel
Keywords
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