FORMULATION AND PHYSICAL STABILITY TEST OF MICROEMULSION GEL OF KETOCONAZOLE
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 11
Abstract
Objective: The purpose of this study was to formulate and evaluate the physical stability of ketoconazole microemulsion gel. Method: Pseudoternary phase diagrams were constructed using tween 80 as surfactant and propylene glycol as co-surfactant. The optimized microemulsion formula containing 5% isopropyl myristate as oil phase, 25% Tween 80 as surfactant, and 25% propylene glycol as co-surfactant. Result: The formulation showed clear and transparent yellowish microemulsion, while the microemulsion gel showed cloudy yellowish color. Globule size in each microemulsion and microemulsion at were 13.38 nm and 184.7 nm; respectively. The flow diagram of the microemulsion gel properties showed the plastic flow properties. The centrifugation and cycling test result showed an unchanged organoleptic, no phase separation occured between microemulsion and gel, no syneresis occured. The result of cycling test and centrifugation test was physically stable. Conclusion: Ketoconazole microemulsion gel show a good stability at temperature 30°C ± 2°C and 40°C ± 2°C.
Authors and Affiliations
Mahdi Jufri
Keywords
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