FORMULATION APPROACHES IN OCULAR DRUG DELIVERY SYSTEM
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex lachrymation and drainage which remove rapidly various foreign substances including drug from the surface of the eye. Frequent instillation of drug solution is necessary to maintain a therapeutic drug level in the tear or at the site of action but the frequent use of highly concentrated solution may induce toxic side effects due to systemic absorption of drug through nasolachrymal drainage. In recent years there has been significant efforts directed towards the development of new systems for ophthalmic drug delivery. This review focuses on recent literature regarding mucoadhesive systems, vesicular systems, semisolid hydrogel and in situ gelling system. Moreover, attempt has been made to explore the applicability of numerous polymers for ocular drug delivery system and also includes a detailed account on various recent strategies that are developed and under development stage so far.
Authors and Affiliations
Sangita kute
Keywords
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- EP ID EP107943
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