Formulation, characterization and evaluation of zidovudine controlled release matrix tablets using HPMC K4M and K100M
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 1
Abstract
The aim of present investigation is preparation, characterization and evaluation of oral controlled release matrix tablets of Zidovudine (AZT) in order to improve efficacy and reduce its side effects. FTIR and DSC confirmed the absence of any interactions between drug, polymer and the excipients. Tablets were prepared by direct compression method using different viscosity grades of hydroxypropylmethylcellulose (HPMC). All the batches were subjected to evaluation parameters such as physicochemical properties, swelling characteristics and in vitro drug release profile. Optimized formulation was subjected for accelerated stability studies as per ICH guidelines at 40 ± 2OC / 75 ± 5% RH. Scanning electron microscopy was used to visualize the effect of dissolution medium on matrix tablet surface. The in vitro drug release study revealed that formulations containing 20, 30 and 40% HPMC K4M were able to sustain up to 8, 10 and 11 hrs respectively where as formulations containing 20, 30 and 40% HPMC K100M were able to sustain the drug release up to 22, 23 and 24 hrs respectively. Release kinetics of (F6) formulation followed Korshmeyer’s Peppas model. In vivo investigation in Wistar rats showed sustained release profile of drug from the F6 formulation for 24 hrs with Cmax of 441.25ng/ml, Tmax of 4 hrs and AUC of 6970.18ng/hr/ml compared to that of conventional marketed tablets with Cmax of 1095.62, Tmax of 1hr. The results suggest that the developed matrix tablets of Zidovudine could perform therapeutically better than conventional dosage form, leading to improved efficacy and better patient compliance.
Authors and Affiliations
Sreelakshmi S, V. Ravi Kumar, Shameer H, Preetam K, T. Shivaraj Gouda
Keywords
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