FORMULATION DEVELOPMENT AND EVALUATION OF SR MATRIX TABLETS OF PEFLOXACIN
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 6
Abstract
The basic objective in dosage form design is to optimize the delivery of medication to achieve the control of therapeutic effect in the face of uncertain fluctuation in the system in which drug release takes place. This is usually concerned with the maximum drug availability by attempting to attain a maximum rate and extent of drug absorption, however; control of drug action through formulation also implies controlling the bioavailability to reduce drug absorption rates. So in the present study, an attempt has been made to formulate sustained release matrix tablets of Pefloxacin. Tablets were prepared using a direct compression method employing natural sustained release polymer such as Xanthum gum in different concentrations. The tablets were evaluated for physical characteristic like hardness, weight variation, friability and drug content. In-vitro release of drug was performed in phosphate buffer pH 6.8 for fourteen hours, percent friability 0.22 % and disintegration time 2.20 h. All the physical characters of the fabricated tablet were within the acceptable limits. The data obtained from in vitro dissolution studies were fitted in different models viz. Zero order, first order, Higuchi and Korsmeyer-Peppas equation. It was also observed that the highest correlation was for Korsmeyer- Peppas profile (R2 = 0. 9938). A value of n for all matrices studied here was ranged between 0.4339 to 0.4840; indicating an anomalous behavior corresponding to swelling, diffusion and erosion mechanism.
Authors and Affiliations
Swatantra Singh
Keywords
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- EP ID EP127102
- DOI 10.7897/2321-6328.02691
- Views 125
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