Formulation, development, and evaluation of tramadol Hcl sustained-release dosage form
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2018, Vol 6, Issue 3
Abstract
Aim: The aim of the investigation was to develop a new formulation of tramadol HCl. Material and Method: Tramadol HCl is, centrally acting analgesic, by improving the prolong action of tramadol HCl drug using hydroxypropyl methylcellulose, ethylcellulose as polymer provides a release of therapeutically active medicament over an extended period of time, for example, from about 12 to 24 h. Tablet formulation was prepared by wet granulation technique. The tablets were compressed (8 mm diameter, standard concave punches) using a rotary tablet compression machine (4 station, Rimek, Ahmedabad, India). Result: The prepared tablets were evaluated for weight variation, hardness, friability, drug content, in vitro dissolution, and stability studies. From the above evaluate parameters, it was concluded that batch B-1 showed good results and was found having optimized concentration of polymers and other additives to prepare a sustained-release tablet of tramadol Hcl. Conclusion: The developed new formulation of tramadol HCl sustained-release tablet is successful.
Authors and Affiliations
Shabnam Thakur
Keywords
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