Formulation, development, and evaluation of tramadol Hcl sustained-release dosage form
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2018, Vol 6, Issue 3
Abstract
Aim: The aim of the investigation was to develop a new formulation of tramadol HCl. Material and Method: Tramadol HCl is, centrally acting analgesic, by improving the prolong action of tramadol HCl drug using hydroxypropyl methylcellulose, ethylcellulose as polymer provides a release of therapeutically active medicament over an extended period of time, for example, from about 12 to 24 h. Tablet formulation was prepared by wet granulation technique. The tablets were compressed (8 mm diameter, standard concave punches) using a rotary tablet compression machine (4 station, Rimek, Ahmedabad, India). Result: The prepared tablets were evaluated for weight variation, hardness, friability, drug content, in vitro dissolution, and stability studies. From the above evaluate parameters, it was concluded that batch B-1 showed good results and was found having optimized concentration of polymers and other additives to prepare a sustained-release tablet of tramadol Hcl. Conclusion: The developed new formulation of tramadol HCl sustained-release tablet is successful.
Authors and Affiliations
Shabnam Thakur
Keywords
Related Articles
- EP ID EP570087
- DOI -
- Views 63
- Downloads 0
Obesity- Causes and it management by herbal drugs
Obesity is one of the most prominent and wide spread diseases throughout the world, affecting each and age group. Obesity has became as of the most prevalent health concerns among all populations and age groups worldwide...
Adherence and Associated Factors towards Antidiabetic Medication among Type II Diabetic Patients on Follow-Up at University of Gondar Hospital, Northwest Ethiopia
Background. The prevalence of diabetes mellitus (DM) is rising worldwide and is more in the developing countries which unfor-tunately are already suffering from communicable diseases. The aim of this study was to assess...
Prevalence of Pseudomonas sp. and their antibiotic sensitivity profile in burn patients
Burns are one of the most severe wounds that damage extensively the first line of defense of the body, the skin, making them easily prone to infections, thus requiring a higher level of containment to prevent infection....
Electrochemotherapy: An enhancement of cytotoxicity of anticancer drugs
Electrochemotherapy (ECT) is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this article, we discuss ECT and review the steps needed to move such a treatmen...
Evaluation of in vitro and in vivo antimalarial activity of Hymenodictyon excelsum bark extracts
The present study was designed to evaluate in vitro and in vivo antimalarial activity of different extracts of Hymenodictyon excelsum bark which is used in the treatment of malarial fever as a febrifuge. The preliminary...