FORMULATION OF POLYMER-NANO COMPOSITE FILM FOR COATING GRASTRORETENTIVE TABLET OF DIPYRIDAMOL AS A MODEL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The aim of this work was to formulate the polymer nano composite film to coat the gastroretentive tablet.Methods: The polymer nano composite film was formulated by varying the concentration of Eudragit® RS/RL 30D, PEG 6000 and with or without sodium bentonite. The polymer nano composite was then used to coat the gastroretentive dipyridamol tablet as a model.Results: The film containing Eudragit® RS/RL 30D at ratio 80:20 with 20 % PEG 6000 (w/w dry polymer) and 2% sodium bentonite (w/w dry clay) (formulation 16) was more elastic and strength. The diffusion test showed that the percentage of dipyridamole passed through the film of formulation 8 (without sodium bentonite) and 16 was superimposed during the 7 first hours and after 7 hours, they split in which the formulation 8 was higher than formulation 16. The floating lag time and capacity of the coated tablet with nano composite were 1’: 53†and more than 8 hours, respectively, while for tablet coated without nano composite were 0’: 09†and 7’: 08’: 27†respectively. The release showed that the gastroretentive dipyridamol tablet coated by polymer nano composite (formulation 16) released dipyridamol 43.59±3.59 and 89.69±4.92% at 4th and 8th hour respectively, while the tablet coated without nano composite (formulation 8) released 44.76±4. 74% and 95.76±1.35% respectively.Conclusions: The polymer nano composite film containing Eudragit® RS/RL 30D with the ratio of 80:20 and 20% PEG 6000 (w/w dry polymer) with the presence of 2% sodium bentonite generated tablet that floated for 8 hours and produced the release of the drug according to the requirement that has been set.Â
Authors and Affiliations
Saleh Wikarsa, Arevin Sandrasekeran, Diky Mudhakir
Keywords
Related Articles
- EP ID EP578866
- DOI -
- Views 59
- Downloads 0
HEPATOPROTECTIVE EFFECT OF VIRGOLIV SYRUP AGAINST CCL4 INDUCED HEPATIC INJURY IN RATS
Objective: To evaluate the hepatoprotective effect of Virgoliv syrup on CCl4 induced hepatic injury in rats.Methods: The hepatic injury was induced by intra peritoneal injection of 0.3 % CCl4 (10 ml/kg) diluted with oliv...
FORMULATION AND CHARACTERIZATION OF ROPINIROLE HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES
Objective: The aim of the present study was to formulate and evaluate the Solid Lipid Nanoparticles (SLNs) of Ropinirole Hydrochloride (ROP).Methods: ROP-loaded SLNs were prepared by a double emulsion method using glycer...
USE OF TRANEXAMIC ACID IN MEGALIPOSUCTION
.
IMPACT OF PHYSICAL TREATMENTS ON STABILITY AND RADICAL SCAVENGING CAPACITY OF ANTHOCYANIDINS
Objective: The aim of the study was to evaluate the chemical stability and antioxidant ability of selected anthocyanidin (ACN) upon various commonly used physical treatments.Methods: Pure compounds of representative ACNs...
PREDICTION OF PROMISCUOUS EPITOPE STUDIES OF SPA ANTIGEN IN STAPHYLOCOCCUS AUREUS: AN INSIGHT ON PEPTIDE-BASED VACCINE
Objective: Owing to the difficulty in providing drug therapies against Methicillin-resistant Staphylococcus aureus (MRSA), the development of an effective and promising vaccine is an immense challenge in combatingMRSA in...