FORMULATION, OPTIMIZATION AND EVALUATION OF STOMACH SPECIFIC IN-SITU GEL OF HYDROCHLOROTHIAZIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 9
Abstract
The objectives of this research work were preparation, optimization and evaluation of in situ gelling system of Hydrochlorothiazide based on pectin that retains in the stomach by adherence to gastric wall providing an increased gastric residence time resulting in prolonged drug delivery in gastrointestinal tract. Pectin was used as a polymer and CaCO3 as a cross-linking agent. The in situ formulation exhibited the expectations, viscosity, drug content and sustained drug release. This study reports that oral administration of aqueous solutions containing pectin results in formation of in situ gel and such formulations are homogenous liquids when administered orally and become gel at the contact site. The results of a 32 full factorial design revealed that the concentrations of pectin and CaCO3 significantly affected the dependent variables of viscosity, drug content (%) and Q18. These in situ gels are, thus, suitable for oral sustained release of Hydrochlorothiazide.
Authors and Affiliations
Saroj Bala , O. P Mahatma , Azim Sabir
Keywords
Related Articles
- EP ID EP98941
- DOI 10.7897/2230-8407.04916
- Views 94
- Downloads 0
NANOPARTICLE: AN OVERVIEW OF PREPARATION, CHARACTERIZATION AND APPLICATION
In the last 30 years, particle size reduction technologies turned from an exploratory approach into a mature commercial drug delivery platform. Nanonization technologies have gained a special importance due to a steadily...
INVESTIGATION OF ANALGESIC AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF STREBLUS ASPER LOUR. (MORACEAE) LEAF AND BARK
The ethanol extract of the leaf and bark of Streblus asper Lour. (Moraceae) was investigated for its possible analgesic effects in animal models and its antioxidant activities. It exhibited statistically significant writ...
PHYTOCHEMICALS AND BIOLOGICAL ACTIVITIES OF FAGONIA INDICA
Fagonia Indica (family Zygophyllaceae) is a small spiny under-shrub, mostly found in the deserts of Asia and Africa. It is widely used is Ayurvedic system of medicine to treat vitiated conditions since this plant was ant...
UNDERSTANDING GOUT BEYOND DOUBT
Life is all about movements and activities. Our entire livelihood and existence comes into trouble, we become immobile and inactive due to joint pains and swelling. Gout is one such condition, which affects an individual...
ETHNOBOTANY, PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF CINNAMOMUM ZEYLANICUM BLUME.
Cinnamomum zeylanicum, popularly known as cinnamon or ceylon cinnamon refers to the tropical evergreen tree as well as the bark that is extracted from the plant. Cinnamon are recognized for its sweet flavour and aroma an...