FORMULATIONAND EVALUATION OF ARIPIPRAZOLE ORO-DISPERSIBLE TABLETS: OPTIMISATION THROUGH FACTORIAL DESIGN OF EXPERIMENTS
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2019, Vol 8, Issue 1
Abstract
The main objective of this study was to prepare and evaluate fast dissolving tablets of aripiprazoleusing three different types of superdisintegrants. Various formulations were prepared by direct compression using different concentrations of superdisintegrant i.e. namely Kyron T-104, Kyron T-154 and Kyron T-314. The compatibility studies between drug and excipients were carried out using Fourier Transform Infrared spectroscopy. The blend was evaluated for additive properties. The tablets formulated using factorial design was evaluated for physical properties andin-vitro drug release. From this study formulation containing Kyron T-154 was found to possess better disintegration time of 15 sec, water absorption ratio(77.5 %), and wetting time (22.7 sec) with taste masking property at low concentration and hence formulation containing was Kyron T-154 optimized.
Authors and Affiliations
P. K. Lakshmi, Ginnarapu Supraja, Ruhi Anjum
Keywords
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- EP ID EP648285
- DOI 10.7897/2277-4572.081123
- Views 49
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