FT-IR STUDY OF THE EFFECT OF ALUMINIUM AND THE INFLUENCE OF DFO AND DFP ON THE BIO-CHEMICAL CHANGES IN THE KIDNEY OF INDIAN CIRRHINUS MRIGALA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Aluminium is naturally occurring, most abundant element in the earth crust and becomes toxic elevated concentrations are introduced into the environment. Kidney is involved in detoxification and high affinity to removal and excretion of toxic substances circulating in the blood stream. The aim of the present work is to find out the effect of aluminium and the influence of DFO and DFP on the bio-chemical changes in the kidney of Indian Cirrhinus Mrigala using Fourier Transformation Infrared Spectroscopy. Various important features have been observed in FTIR spectra of aluminium intoxicated kidney of Indian Cirrhinus Mrigala, altered lipid and protein profile and increased amide II content, indicating an alteration in the lipid and protein profile leading to modification in membrane composition. Further it is observed that acute exposure to aluminium causes some alteration in protein and amide II and increased in coil structure of alpha helix. Chelating agent DFO and DFP reduces the bio-chemical content in the kidney of Indian Cirrhinus Mrigala. Both the chelating agents are based antidote for aluminium toxicity.
Authors and Affiliations
S. Sivakumar, Khatiwada Prasad, J. Sivasubramanian
Keywords
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