G6PD deficiency and Thalassemia: Is there any correlation? An institutional study from Northern India
Journal Title: Journal of Medical Research and Practice - Year 2018, Vol 7, Issue 1
Abstract
Introduction Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited red blood cell (RBC) enzyme disease, affecting 10% of the world population. It is an X-linked disorder transmitted by gene of intermediate dominance causing hemolytic anemia and neonatal hyperbilirubinemia. Aim The aim was to find out the incidence of G6PD deficiency in thalassemic patients, to study the age and sex distribution and to screen the parents, siblings, and relatives of these patients for this defect as far as possible. Materials and Methods About 150 β-thalassemic patients visited thalassemia ward in Rajindra Hospital, Patiala, were screened for G6PD deficiency by qualitative G6PD test kit assay (Dye decolorisation test). Those individuals who had a history of blood transfusion in past 3 months were excluded from the study. Results Out of 150 cases, 118 were males and 32 were females. Two males were deficient to G6PD and none of the female subjects. The overall incidence of G6PD in this region of Punjab in β-thalassemic patients was found to be 1.3%. The incidence rate was 1.42% among Hindus and 1.28% among Sikhs. All G6PD deficient subjects were Rh+, with 2.08% having blood group B and 2.27% having blood group O. Conclusion The incidence of G6PD deficiency among β-thalassemia subjects is same as that of general population. This study among thalassemic patients is important as the deficient persons can be advised to avoid certain oxidant drugs and foods. Relatives of the deficient subjects can also be screened and advised accordingly, as it is a genetically determined trait.
Authors and Affiliations
Parampreet Kaur, Rupinder Kaur Brar, Anil Kumar Suri, Navneet Kaur
Keywords
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