Genetic variability of KiSS-1 and GPR-54 genes and its infulence on animal reproduction. A review
Journal Title: Journal of Animal Science, Biology and Bioeconomy - Year 2015, Vol 33, Issue 4
Abstract
Kisspeptyn (KiSS) and its constitutive receptor GPR-54 play a key role in the regulation of the hypothalamic-pituitary-gonadal (HPG), affecting, for example, activation gonadotropin axis in adolescent humans. Mutations in the gene KiSS-1 and GPR-54 may play an important role in the pathogenesis of CPP (early puberty) and the IHH (idiopathic hypogonadotropic hypogonadism). The role of variation in gene sequences KiSS1/GPR54 in other mammals is not well known, and the relationships of polymorphisms with parameters of reproductive performance of livestock are divergent and require further studies.
Authors and Affiliations
Urszula Kaczor, Kamil Brutkowski, Mirosław Kucharski, Andrzej Kaczor
Keywords
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