Genotoxic and Cytotoxic Effects of Cone Beam Computed Tomography on Exfoliated Buccal Epithelial Cells
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Cone beam Computed Tomography (CBCT) is a valuable diagnostic aid. It provides three dimensional detailed images of the region of interest with good quality. It allows volumetric analysis and it has short scan times. Ionizing radiation emitted from different radiographic procedures may induce DNA damage and genomic alteration. Genomic damages can be assessed and evaluated by numerous methods. The present study was accomplished to evaluate genotoxicity and cytotoxicity in exfoliated buccal mucosa cells of adults following CBCT exposure. Materials and Methods: 30 healthy male patients were recruited from outpatient’s clinic of Faculty of Dentistry Pharos University of age ranging from 27 to 43 years. All patients were submitted to CBCT. Exfoliated buccal cells were collected immediately before CBCT and after 10 days. The cytological smears were examined to detect micronuclei and other cytological alterations. Results: The mean frequencies of micronuclei and the other nuclear changes (pyknosis, condensed chromatin and karyorrhexis) showed a significant increase after CBCT exposure. Though, the increase in both parameters was not statistically significant in correlation with patients’ age. Conclusion: From the current study, the authors concluded that CBCT has inevitable health side effects. Hence, it must be used following the ALARA principle.
Authors and Affiliations
Soha Basha, Marwa Essawy
Keywords
Related Articles
- EP ID EP369182
- DOI 10.9790/0853-1703056670.
- Views 47
- Downloads 0
Biopsy- A Crucial diagnostic aid for oral lesions
Biopsy is a valuable aid in diagnosis of diseases which consists of obtaining a specimen of living tissue in order to study its structure, both macro and microscopically. This procedure makes it possible to confirm or de...
A Study of Clinical, Hematological and Etiological Profile of Pancytopeniaat a Tertiary Care Center in Andhra Pradesh, India.
Background: Pancytopenia is a triad of anemia, leucopenia and thrombocytopenia. The initial symptom would be generalized weakness. Etiology ranges from benign to malignant conditions. Accurate workup is essential for the...
Knowledge of Palliative Care among Nurses in a Tertiary Hospital in Manipur
Background: With the rising burden of non-communicable diseases and ageing population, the need for palliative care (PC) will continue to grow. Nurses who are the primary caregivers to the hospitalized are expected to po...
Analysis of the types of breast pain-a retrospective study
Purpose: To determine the most common type of breast pain and presence of malignancy in breast pain patients. Methods: We conducted a retrospective analysis of the symptoms, clinical examination findings and breast imagi...
Analysis of Results of Closed Unstable Lower Third Tibial Fractures Treated With Interlock Intra-Medullary Nailing
This study aims in evaluating the functional and radiological outcome following intramedullary interlocking nailing (IMIL) in closed lower third tibialfracture.This prospective and retrospective study includes 15 patient...