Genotypic Distribution of Hepatitis B Virus in different Spectrum of its Viral Load in a Tertiary care Hospital in Northern India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 9
Abstract
Hepatitis B virus (HBV) genotyping is of clinical relevance to clarify the route, virulence, serologic reactivity pathogenesis and response to antiviral therapy. Current study characterizes the HBV genotypes and its distribution with respect to different spectrum of HBV DNA viral load. The distribution of different HBV genotypes among patients with relevance to DNA quantification was evaluated. 108 HBsAg positive serum specimens were considered, where 05 cases for HBV DNA viral load came negative and 08 samples fails to amplify. Further 95 HBV positive specimens were subjected for genotyping and HBV viral load was estimated. All the cases were categorized in the increasing order of their HBV DNA load into three groups as; 1.00x101-1.00x103, 1.01x104-1.00x106 and above 1.00 x106 IU/ml of HBV DNA with 58, 22 and 15 HBV positive cases respectively in these groups. HBV genotype D was the most prevalent in cases with higher viral load followed by Genotype C and B. The percentage of HBV genotypes D, C, B, A, E and F was 45.2%, 24.2%, 17.8%, 12.6%, 8.4% and 5.2% respectively. High HBV DNA viral load was seen in the age group 21-40 and 41-60 years. In conclusion HBV viral DNA titer was elevated in HBV genotype D, followed by genotype C and B assuming that HBV genotype D is the most replicated virus & need to be monitored thoroughly during the diagnosis that could potentially influence the outcome of chronic hepatitis B and the success of antiviral therapy. Keywords: Hepatitis B virus, Real Time PCR, Chronic Hepatitis, Viral load, Hepatocellular carcinoma
Authors and Affiliations
Narotam Sharma, Rakhi Kaushik, Satish C Nautiyal, Rajendra Singh, Aman preet Singh, Sugam Birthare
Keywords
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