Glaucoma Progressing Stage Estimated from Visual Field Test Data with Glaucoma Patient; and Zinc(II) Induced Regenerative Activity from Optic Nerve Damage

Journal Title: Journal of Medical Research and Surgery - Year 2021, Vol 2, Issue 5

Abstract

Glaucoma progressing stages (Stages 1~5) estimated from Visual Field Index (VFI); Mean Deviation (MD); and Pattern Standard Deviation (PSD) data has been elucidated; in which the glaucomatous pathology is in the proceeding stage 2-3 with T. Ishida's glaucoma patient compared with referring with VFI; MD; and PSD values to the literatures. Zinc(Ⅱ) induced VFI improvement should be taken into account when interpreting rates of VFI change over time that zinc promotes Retinal Ganglion Cells (RGCs) survival; in which zinc intake in RGCs survival may be zinc acetate 25-50 mg/day. Zinc(Ⅱ) induced recovery activity from optic nerve damage of the eye consists of four processes as follows. (1) Intraocular inflammatory stimulation process; Zinc concentrations 123-292 μg/g inhibit intraocular inflammation with atypical growth factor Oncomodulin (OCM) binding to its cognate receptor on RGCs. (2) RGC survival process; Zn2+ chelators enhance RGC survival and promote axon regeneration through the optic nerve. (3) Neural axon regeneration process; Zn2+ chelation promotes axon regeneration. Norepinephrine Transporters (Net) inhibitor promotes RGCs survival and axonal regeneration. (4) Eye to brain pathway process; Zn2+ chelator TPEN promotes both enduring RGC survival and considerable axon regeneration. Zinc induced recovery for NO production in RGCs that the NO conveys from the eye to the brain through the axons of RGCs; in which zinc concentration 100 μM may be suited for the optic nerve recovery. Accordingly; Zinc(Ⅱ) could enhance optic nerve damage recovery that Zn2+ may be bound with optic nerve damage proteins; in which Zn2+ ions may bind with intraocular protein; RGC survival protein; axonal protein; and optic nerve disorder proteins during recovery process by Zn2+ ions-centered tetrahedrally binding proteins molecular coordination pattern.

Authors and Affiliations

Tsuneo Ishida*

Keywords

Related Articles

Creatine Derivatives: Rapid Complete Relief of Pain by Topical or Transcutaneous Administration

Our research reveals that non-toxic creatine derivatives, especially N-acetyl-creatine ethyl ester, to be therapeutically effective on topical application or by superficial subcutaneous injection over sites of pain to ra...

Use of External Approach for Severe Genu Valgo Knee Arthroplasty

The deformities of the lower limbs (genu valgus and genu varus) are alterations frequently developed properly by physiological processes which usually disappear at 2 years (genu varus) and at 7-8 years (genu valgus), bei...

Pedicled Anterolateral Thigh Flap As A Workhourse Flap for Reconstruction of Inguino-Scrotal Defects

Background: Reconstructions around inguinoscrotal region has been a challenging task owing to complex anatomy. There are variety of flap options available for reconstruction of Inguinoscrotal region. Our study was done t...

A Novel Technique of Biological Osteosynthesis in a Bicondylar Tibial Fracture

Purpose: To evaluate the biological treatment outcomes for tibial plateau fractures. Methods: 8 men and 4 women aged 21 to 54 (mean, 36) years with closed tibial plateau fractures were enrolled for the study. Accordin...

Anticoagulation in the Treatment of Pulsatile Tinnitus Caused by Internal Jugular Vein Stenosis: A Rare Case Report

Background: Anticoagulation is considered as a first line treatment of pulsatile tinnitus caused by internal jugular vein thrombosis. We present a case of non-thrombotic internal jugular vein occlusion which responded to...

Download PDF file
  • EP ID EP697647
  • DOI 10.52916/jmrs214057
  • Views 31
  • Downloads 0

How To Cite

Tsuneo Ishida* (2021). Glaucoma Progressing Stage Estimated from Visual Field Test Data with Glaucoma Patient; and Zinc(II) Induced Regenerative Activity from Optic Nerve Damage. Journal of Medical Research and Surgery, 2(5), -. https://europub.co.uk/articles/-A-697647