Growth inhibitory activity of selected microalgae and cyanobacteria towards human cervical carcinoma cells (HeLa)
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 12
Abstract
Although a large number of strains have been shown to possess anticancer activity, the microalgal and cyanobacterial potential is still largely unexplored. The present study was aimed to evaluate and compare the growth inhibitory activity of 33 extracts, 15 fatty acid mixtures and five exopolysaccharides from 19 species on HeLa cells, using MTT assay. All investigated strains showed growth inhibitory activity of at least one tested extract/constituent. More than 80% decrease in Hela cells viability was registered for the crude hot water extract of Gloeocapsa sp. and ethanol extracts of the new Bulgarian isolates Gloeocapsa sp. and Chlorella sp. Most active cell-free culture liquids were these of Anabaena sp. and Synechocystis sp., while the exopolysaccharides of Gloeocapsa sp. exhibited the lowest IC 50 value (24.4 µg/ml). An interesting and useful finding of our investigation was that the isolated fatty acid mixtures from five out of eight cyanobacterial strains and from four out of seven microalgal strains studied had potent activity against HeLa tumor cells with the IC 50 values under 30 µg/ml and even under 15 µg/ml. High percentage of the active Bulgarian isolates among the strains tested fulfil the effort of screening cyanobacteria and microalgae of local habitats. In conclusion, the most promising strains for further study are the thermal cyanobacteria Synechocystis sp. and especially Gloeocapsa sp., which showed the strongest inhibition of tumor cell growth and produced wider range of active components.
Authors and Affiliations
Liliana G. Gigova 1* , Reneta A. Toshkova 2 , Elena G. Gardeva 2 , Gergana V. Gacheva 1 , Natalia J. Ivanova 1 , Liliya S. Yossi
Keywords
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