Hair-growth promoting activity of plant extracts of suruhan (Peperomia pellucida) in Rabbits
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Efforts in seeking effective medicine for preventing hair loss and promoting hair growth are still continues worldwide. This study investigate effects of ethanolic plant extract of suruhan, Indonesian name for Peperomia pellucida (L.) Kunth., on rabbit hairs growth. Four healty, male rabbits, aged 4-5 months, weighing 1.5 kg – 2 kg were used for the study. Six areas (2 cm x 2 cm each) on the dorsal aspects of animals were shaved and marked C-, C+, S1, S2, S3 and S4. Area C- and C+ are the shaved skin treated consecutively with CMC gel without suruhan extract (as negative control) and 2% minoxidil (as positive control). Area S1, S2, S3 and S4 are the shaved skin treated with gel containing suruhan extracts of 25% (v/v), 50% (v/v), 75% (v/v) and 100% (v/v) respectively. All treatments were given twice daily for 21 days. The length of hairs were assessed on day 7, 14 and 21, while the hair mass was measured on day 22. The results showed topical CMC gel containing ethanolic plant extracts of suruhan significantly increase the animal hairs length in a concentration-related manner. However, in comparison to both negative and positive controls, suruhan plant extracts show no significant effect on hair mass of the animals. It suggests that ethanolic plant extract of Peperomia pellucida is potent to be used as the topical formulations for hair growth.
Authors and Affiliations
Mohammad Kanedi1, Martha Lulus Lande, Nuning Nurcahyani1, Indria Ratna Anggraeni1, Yulianty1 .
Keywords
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- EP ID EP391251
- DOI 10.9790/3008-1205061823
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