Hematological and Biochemical Results of Patients with Campylobacter Infection At King Fahd Hospital, Riyadh, Saudi Arabia.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 2
Abstract
Objectives: The hematological and biochemical changes due to multi-organ involvement in enteritis are common. The aim of this study was to determine the frequency and severity of the above changes in patients admitted to the hospital because of enteritis.Methodology: This was a hospital based descriptive study conducted at the infectious diseases unit and medical wards at King Fahd Hospital, Riyadh, Saudi Arabia, from 2010 to 2013. The study was designed to include demographics, hematological and biochemical changes observed in each patient. Only patients whose stool yielded Campylobacter species were included in the study. Full blood count, liver function tests, stool culture, urea, electrolytes, and coagulation profile were performed for all the patients. Results: Data on 91 patients with Campylobacter infection, corresponding to the same number of patients, were reported, including 45 (49.45%) in 2010, 28 (30.77%) in 2011, 9 (9.89%) in 2012 and 2013. Of the total number of isolates, 60 (65.93%) were from patients <20 years of age, 21 (23.08%) were from patients 20-45 years of age, 8 (8.79%) were from patients 46-71 years of age and 2 (2.19%) were from patients >71 years of age. The sensitivity of Campylobacter species to erythromycin was higher in 2010 (48.86%) compared to 2012 and 2013 (10.23%). However, two female patients were resistant to erythromycin in 2010 and one male in 2011.The most common hematological changes observed were anemia (46.2%), lymphopenia (76.9%), Neutrophilia (78%), leukocytosis (57%) & leucopenia (2.2%). Whereas, the biochemical changes included raised alkaline phosphatase (72.5%), creatinine (50.5%), potassium (44%), and blood urea (36.3%), while the serum albumin was found to be low in 78%. All patients were discharged in good health once hematological and biochemical changes returned to reference range.Conclusion: Campylobacter foodborne disease could cause significant hematological changes and hepatic dysfunction. The involvement of liver was associated with high frequency of extrahepatic complications. Despite the high incidence and serious nature of the hematological changes and liver involvement, these changes are transient and respond favorably to the appropriate antimicrobial therapy.
Authors and Affiliations
Shoeb Qureshi
Keywords
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