Hemodialysis with Polymethylmethacrylate Restores the Response to Hepatitis B Vaccination in Chronic Dialysis Patients: Hypothesized Mechanism of Action
Journal Title: Archives of Renal Diseases and Management - Year 2016, Vol 2, Issue 1
Abstract
Patients undergoing hemodialysis often present with a reduced response to anti-hepatitis B virus (anti-HBV) vaccination. The soluble form of CD40 (sCD40) is elevated in hemodialysis patients and this has been shown to correlate with lack of response to anti-HBV vaccination. Due to its high molecular weight, conventional dialyzers cannot clear sCD40. Previous studies have demonstrated, that dialysis membranes in polymethylmethacrylate (PMMA) can reduce the levels of sCD40. We have studied the effect of dialysis with PMMA membranes in patients who were non-responders to anti-HBV vaccination after a complete cycle of vaccinations. Interestingly, we found that significantly more patients in the PMMA group were able to mount a response to vaccination, compared to the control group (P = 0.04).
Authors and Affiliations
Chiara Ralli, Patrizio Imperiali, Claudio Gabbrilelli, Paolo Conti, Marco Lombardi, Antonino Sidoti, Alessandro Capitanini, Adriano Piluso, Seble Tekle Kiros, Diletta Duranti, Ennio Duranti
Keywords
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- EP ID EP343380
- DOI 10.17352/2455-5495.000006
- Views 98
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