Hemodynamic Responses to Microlaryngoscopy in ENT Patients -A Comparative Study of Premedication with Oral Clonidine and Metoprolol
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 4
Abstract
Introduction: Attenuation of the hemodynamic responses to microlaryngoscopy in ENT patients is achieved using various drugs. Premedication with clonidine and metoprolol produce stable hemodynamics and a reduction in the amount of anaesthetic required. Materials and Methods : This is a prospective randomized double-blind study conducted to compare the effects of two such drugs clonidine and metoprolol given as oral premedication. Forty patients were premedicated 90 minutes prior to the procedure with oral clonidine and placebo in one group and metoprolol and diazepam in the other group and were anaesthetised using a standardised anaesthetic technique. Heart rate, systolic, diastolic and mean arterial blood pressures were recorded and the changes from baseline to those values during and after scopy were compared. The time interval from reversal to extubation and the sedation score at the end of the surgery were also noted. The statistical analysis of the data was done using student’s T-test. Results : The mean of the differences in heart rate from baseline value to scopy at 5 minutes was 13.6 ± 11.26 for clonidine and 12.05 ± 9.42 for metoprolol P=0.64 and that of mean blood pressure was 16.5 ± 8.75 and 13.45±9.69 P=0.30. There were no statistically significant differences between the two groups in the attenuation of cardiovascular response. The sedation produced by clonidine was comparable with that of diazepam. Conclusion: Both clonidine and metoprolol were equally effective in attenuating the hemodynamic responses to the procedure.
Authors and Affiliations
Sunitha K. Zachariah, Sara Ninan
Keywords
Related Articles
- EP ID EP39923
- DOI -
- Views 259
- Downloads 0
Gestational Age Related Study on Morphology and Morphometry of Human Foetal Suprarenal Gland
Introduction: Suprarenal gland shows variation in morphology and morphometry during prenatal stage of development. Kidney suprarenal ratio presents characteristic change from foetal to postnatal life. Objectives: Object...
The study of auditory and visual reaction times in chronic smokers
Audio-visual reaction time is a reliable indicator to assess the processing capability of central nervous system and sensory motor performance in response to an external stimulus. The present study was aimed to find ou...
Effect of Iron Deficiency Anemia on Glycosylated Hemoglobin Levels in Non Diabetic Indian Adults
Glycosylated hemoglobin (HbA1c) is used as a gold standard for monitoring glycemic control and as a predictor of diabetic complications. Conditions that effect erythrocyte turnover affect HbA1c concentration. Although m...
Evaluation of Iron Stores in Blood Donors by Estimation of Serum Ferritin level
Context: Regular blood donation can lead to iron deficiency as well as iron deficiency anaemia. Screening of voluntary blood donor’s serum ferritin levels at the time of donation is very important to estimate the iron...
Otomycosis : A Clinico Mycological Study
Introduction: Otomycosis is a common fungal infection of the ear that is seen in the tropical and sub tropical regions of the world. Objective: The aim of this study was to determine the prevalence of fungal agents and...