HEPATIC ADENOMATOSIS – A CLINICALLY CHALLENGING RARE LIVER DISEASE
Journal Title: INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY - Year 2019, Vol 3, Issue 3
Abstract
43-year-old lady presented with incidentally discovered liver lesions while she was being managed for her complaints of menorrhagia. CT and MRI showed hepatomegaly with multiple lesions in both lobes of the liver with vascular element in the background of diffuse fatty infiltration. Patient underwent laparoscopic core biopsy. Histopathology showed extensive steatosis, intracytoplasmic giant mitochondria and absence of portal tracts, features highly suggestive of hepatic adenomatosis. IHC staining showed membranous and cytoplasmic positivity in hepatocytes for B-catenin consistent with multiple hepatic adenomatosis. Hepatic adenomatosis is a new clinical entity in the hepatological practice characterized by the presence of 10 or more nodules in the liver known for its major complication of bleeding. Hepatic adenomatosis is managed by regular imaging and resection of large (> 5cm) superficial and painful adenomas along with liver function tests and tumor markers to rule out malignant transformation. However, the potential cure being the liver transplantation.
Authors and Affiliations
Dr. Sunitha Ramachandra, Dr. Lakshmi Rao, Dr. Masoud Al Kindi
Keywords
Related Articles
- EP ID EP656857
- DOI -
- Views 50
- Downloads 0
CORRELATION OF MALARIA POSITIVE CASES WITH REFERENCE TO PLATELET COUNT AMONG PATIENTS ATTENDING TMMC&RC, MORADABAD, (U.P)
Introduction: Malaria is one of the major health problems in tropics with increased morbidity and mortality. Mortality rate is generally high in severe malaria whereas haematological changes are most common presentation...
FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRANIAN PATIENTS WITH BLADDER CANCER, KERMAN, SOUTHEAST OF IRAN
To investigate the frequency of human papillomavirus (HPV) in the bladder transitional cell carcinoma (TCC),One hundred twenty paraffin embedded TCC samples were tested for the presence of HPV DNA by Real Time PCR. A con...
UPREGULATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF PD-1 GENE (RS10204525) IN CHRONIC HEPATITIS B PATIENTS
BACKGROUND: Programmed death-1 (PD-1) is major inhibitory molecule that reduces T cell activation. PD-1 and their polymorphisms have separately been shown to be associated with hepatitis B virus (HBV) infection. Therefor...
MORPHOLOGICAL SPECTRUM OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS- A SEVEN YEAR STUDY FROM CENTRAL INDIA
INTRODUCTION: Tumors of the nervous system are important cause of cancer-related deaths in children. There are several reports regarding the epidemiology of CNS tumors in children in the Western literature but too few re...
HAEMATOLOGICAL AND BIOCHEMICAL MANIFESTATIONS OF CHRONIC KIDNEY DISEASES IN TERTIARY CARE HOSPITAL OF TELANGANA
Objectives: Aim of the study was to study the hematological and biochemical manifestations of chronic kidney disease (CKD) and to correlate the hematological abnormality with the clinical stage. Methods: A total of 112 h...