HEPATOPROTECTIVE EFFECT OF PHYLLANTHUS NIRURI ALKALOID FRACTION IN D–GALACTOSAMINE INDUCED HEPATITIS IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 5
Abstract
Objective: The current study was designed to explore the hepatoprotective activity of Phyllanthus niruri (PN) alkaloid fraction in induced hepatitis in rats.Methods: The rats are divided into 5 groups as per the experimental design. Pre alkaloid treatment of PN was given to the hepatitis rats for 21 d. After completion of the treatment, the serum was collected, and biochemical analysis was carried out. The hepatic markers like alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, bilirubin (BL) urea (UR), creatinine (CR) levels are estimated in serum.Results: ALT, AST activities, BL, CR levels are increased, and UR levels are decreased in hepatitis rats. However with PN alkaloid fraction pre-treatment all these hepatic markers significantly (P<0.01) came back to near normal levels. Histopathological studies also prove that PN protected the hepatic tissue from hepatitis.Conclusion: The outcome of the present study showed that the alkaloid fraction of PN possesses hepatoprotective effect in hepatitis rats.Keywords: Phyllanthus niruri, Hepatitis, Liver markers
Authors and Affiliations
Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Gangaraju Doraswamy, Shakuri Ravi, Gangiginta Venkata Subbaiah, Kurakula Srinivas, Kesireddy Sathyavelu Reddy
Keywords
Related Articles
- EP ID EP577628
- DOI -
- Views 42
- Downloads 0
RADICAL SCAVENGING ACTIVITY OF TRITERPENE STEROIDS FROM STEM OFPOLYGONUM PULCHRUM Bl
Objective: P. pulchrum grows abundantly in Kendari (Sulawesi Tenggara province, Indonesia).However, there is no report neither chemical contents nor biological activitiesof the plant. This project studiesthe isolation, s...
HEPATOPROTECTIVE EFFECTS OF PUNICA GRANATUM FRUIT AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN RATS: IN VITRO AND IN VIVO STUDIES
Objective: Hepatoprotective activity of Punica granatum Linn. (Family: Punicaceae) was evaluated by in vitro and in vivo model. HepG2 cell lines were used for in vitro study and D-Galactosamine (D-GalN) induced hepatic d...
FORMULATION AND EVALUATION OF AN HERBAL ANTI-INFLAMMATORY GEL CONTAINING TRIGONELLA FOENUM GREACUM SEED EXTRACT
Objective: The present study was aimed to develop topical gel containing Trigonella foenum greacum (fenugreek) seed extract using carbopol-934, Hydroxypropyl methylcellulose K4M (HPMC K4M) as gelling agents and to invest...
HPLC-PDA METHOD FOR THE QUANTIFICATION OF PARACETAMOL IN PLASMA: APPLICATION TO PK/PD STUDIES WITH ARTHRITIC RATS
Objective: To develop and validate an easy, rapid, sensitive and selective high-performance liquid chromatography with photodiode diode-array (HPLC-PDA) detection method for quantification of paracetamol and to demonstra...
PILL BURDEN, DRUG CLASS DISTRIBUTION AND FINANCIAL BURDEN FOR BUYING MEDICINES IN DIFFERENT MODALITIES OF CHRONIC KIDNEY DISEASE PATIENTS: CROSS-SECTIONAL STUDY
Objective: The objective of the study was to assess the pill burden (PB), drug class distribution and financial burden for buying medicines in different treatment modalities of chronic kidney disease (CKD) patients. Meth...