Hereditary angioedema and gastrointestinal complications: Case report
Journal Title: Medpulse International Journal of Microbiology - Year 2019, Vol 9, Issue 1
Abstract
Background: Hereditary angioedema (HAE) caused by C1-esterase inhibitor(C1-INH) deficiency is an autosomal dominant disease resulting from mutation in the C1-inhibitor gene. In classic HAE, abdominal attacks are mostly characterized by pain, vomiting and diarrhea. Case presentation: A 34 year old female presented with a 12 years history of episodic severe cramping abdominal pain, associated with vomiting and diarrhea. Each episode lasted for a few days and would resolve spontaneously. All the laboratory investigations performed during the episodes were normal except C4 level (< 8 mg/dl) and C 1 esterase inhibitor functional activity (5%) and normal C1 inhibitor level (0.41 G/L) supporting diagnosis type II HAE. Discussion: Hereditary angioedema is a rare genetic disorder. Gastrointestinal tract involvement is an important feature and one of the most common in HAE. Patients suspected of having angioedema should be screened by measuring C4 levels which are typically low except between episodic phases. If the C4 level is decreased, antigenic and functional levels of C1-INH should be measured to confirm the diagnosis. Conclusion: In summary, the diagnosis of angioedema should be considered in any patient with recurrent abdominal pain of obscure origin. There may not be any abnormal findings between attacks, therefore a comprehensive history and physical examination is of utmost importance
Authors and Affiliations
V V Chincholkar, V J Dhole
Keywords
Related Articles
- EP ID EP486234
- DOI 10.26611/1008911
- Views 79
- Downloads 0
Hereditary angioedema and gastrointestinal complications: Case report
Background: Hereditary angioedema (HAE) caused by C1-esterase inhibitor(C1-INH) deficiency is an autosomal dominant disease resulting from mutation in the C1-inhibitor gene. In classic HAE, abdominal attacks are mostly c...
Speciation and resistotyping of coagulase negative staphylococci from clinical samples in a tertiary care hospital
Background: Coagulase negative Staphylococci (CONS) are the indigenous flora of the human skin and mucous membrane. They have long been considered as non-pathogenic and were rarely reported to cause severe infections. Ho...
ESKAPE pathogens: Trends in antibiotic resistance pattern
Background: Trend in resistance pattern of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter, Pseudomonas aeruginosa, and Enterobacter/E.coli species) pathogens and their prevailin...
Seroprevalence of HIV infection in thalassemia patients in a tertiary care hospital
Background: The general incidence of thalassemia trait in India varies between 3 and 17%. Children with thalassemia are susceptible to HIV because they receive multiple blood transfusions. Prevalence of HIV infection in...
Comparison of rapid test and conventional staining methods for the diagnosis of malaria in a tertiary care hospital
Rapid diagnosis is extremely important for effective treatment and reducing the mortality and morbidity of malaria. Therefore, study was undertaken to compare the efficacy of conventional staining methods (Leishman stain...