HIGH-CALORIE DIET AS A FACTOR OF OBESITY DEVELOPMENT IN RATS
Journal Title: Naukovyi visnyk Chernivetskoho universytetu. Biolohiia (Biolohichni systemy) - Year 2014, Vol 6, Issue 2
Abstract
Increase intake of foods with high calorie content can carry some risk of obesity, and to provoke the emergence of such pathological conditions as pereddiabetic condition, type 2 diabetes and metabolic syndrome. Discovery of the mechanisms underlying the violation of metabolic processes in the body when receiving a significant amount of high-calorie foods, can afford to offer a new and promising approach to the correction of pathological conditions associated with these disorders. Given the preliminary data on the involvement of serotoninergic system in the development pereddiabetic status and type 2 diabetes, is of some interest analysis of the components of this system in the development of obesity, which is caused by the consumption of large quantities of high-calorie foods. The analysis of the development of obesity in rats that were on highcalorie diet, which consisted of a standard feed (60%), animal fat (10%), eggs (10%), sugar (9%), peanuts (5%), milk (5%) and sunflower oil (1%). Shown a significant change in parameters such as feed intake, final body mass index Li, body mass index, in the group of rats treated with high-energy diet. Found changes in these indicators show the excessive accumulation of body weight in rats of the experimental group as a result of hyperphagia. Analyzed the content of serotonin in blood serum and brain of experimental animals using ion-exchange method of chromatography on CMsepharose. Shows the change in the content of serotonin in the brain and serum of animals that eat high-calorie foods, indicating a direct involvement of serotoninergic system in the pathogenesis of obesity. Past studies have shown some promising a more in-depth analysis of individual components of the metabolism of serotonin by obesity caused by consumption of excessive amounts of energy-dense foods.
Authors and Affiliations
T. P. KARPOVETS, N. V. SHABANOVA, V. V. KONOPELNYUK, O. M. SAVCHUK, L. I. OSTAPCHENKO
Keywords
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