Histological study of the embryogenesis of metencephalon in preimplantation of albino rat's embryos after maternal treated with silver nanoparticles
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Cerebellum is the most important and critical part of the central nervous system, cerebellum is very sensitive to the abnormal changes during the embryological development in its histological structure, the exposure to any infection during embryogenesis produce abnormalities in the cerebellum and behavioral of offspring. In this study we tried to study the ontogenesis of the cerebellum in the embryos of the albino rats and detection the effect of the AgNPs on the ontogenesis of the rat cerebellum after exposure of AgNPs during pregnancy. we used 60 female pregnant rats divided in to three group, each contain 20 female, (G1) treated with 2mg/kg /day suspension of silver nanoparticles (Ag NPs) (G2) treated with 20mg/kg/day AgNPs from first day of pregnancy until delivery at 21 days and (G3) was considered the control group received D.W only. We were select the embryonic day (ED 7,12,15,18 and 21). The results showed apoptosis, degenerative and dispersion in glial cell in the internal granular layer of cerebellar cortex and less dense of external granular layer due to AgNPs may pass the blood brain barrier (BBB) to the embryo’s brain when female exposure to the AgNPs during pregnancy.
Authors and Affiliations
Esraa H. Ali, Lina A. Salih
Keywords
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- EP ID EP393351
- DOI 10.9790/3008-1301032934
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