Histomorphometric and Histologic Evaluation of Nano-HA with and without PRGF in Bilateral Sinus Lift Augmentation: A Randomized Clinical Trial
Journal Title: Journal of Research in Medical and Dental Science - Year 2017, Vol 5, Issue 3
Abstract
Background and Aim: Positive results were reported after application of plasma-rich in growth factors (PRGF) in sinus elevation augmentations. Furthermore, PRGF products are available in different formulations and using them along with different graft biomaterials possibly induces bone formation and remodeling. This study assessed the histologic and histomorphometric results of NanoBone® biomaterial with and without PRGF in bilateral sinus augmentations. Materials and Methods: In this randomized split-mouth clinical trial, 10 patients who needed sinus floor elevation were selected and activated liquid PRGF was obtained through centrifuge of their blood. The space between alveolar process and sinus floor were filled with NanoBone® + PRGF (test site) or NanoBone® alone (control site) post-surgery. After 6 months, the implants were inserted in the regions and bone specimens were obtained using trephine burs. The sections were prepared by the standard techniques and bone remodeling was examined in both groups. The data were subjected to paired t test. Results: In case sites, the mean new bone formation percentages were 30.29%±8.54 and 30.84% ±6.76 in control sites. The mean remnant particles were 26.16%±10.03 and 26.18%±10.09 in case and control sites respectively. No significant differences were noted between case and control sites regarding mean new bone formation and remnant particles. Chronic inflammation was noted in all specimens with dominant range of 10-30%. The giant cells were evident and all specimens showed bones of lamellar and woven types. Conclusion: Although no significant differences existed between the sites filling using NanoBone® with and without PRGF in bilateral sinus augmentations, the results are probably related to the lengthy time periods for specimen preparation and the type of bone materials used. Conclusion was that PRGF did not induce bone formation in the aforementioned period of time.
Authors and Affiliations
Mansour Meimandi, Anahita Ashouri Moghaddam, Gholam Ali Gholami, Fatemeh Mashadi Abbass, Mostafa Solati
Keywords
Related Articles
- EP ID EP344220
- DOI -
- Views 135
- Downloads 0
Postoperative sensitivity after placement of bulk-fill posterior restoration
The purpose of this observational retrospective clinical study was to assess the post-operative sensitivity reported by patients following the placement of bulk-fill composite restorations. Patient records of the seventy...
The Effect of Synthetic Grape Seed Extract (GSE) on the Shear Bond Strength of composite resin to Dentin
Proper bonding to dentin depends on efficient infiltration of resin into the demineralized microporous collagen and formation of hybrid layer. Grape Seed Extract (GSE) has up to 97% PA and can potentially stimulate colla...
The prevalence of infection in women using IUDs
Nowadays over 153 million women use IUD in worldwide, as contraception. Long-term, high effective, and cost effective are advantages this method. This study was conducted to access side effects and prevalence of them of...
Improvement of Adherence to Treatment in People with Diabetes: An Iranian Perspective
Essential part of diabetes control is adherence to treatment regimen. Improvement of adherence to treatment is a growing priority for health care systems, which has been less considered in Iran. This study evaluates pers...
Comparison of Intertan Nail Vs. Proximal Femoral Nail in Proximal Femoral Fractures – A Prospective Comparative Study
Incidence of peritrochanteric fractures has increased significantly during recent decades and this tendency will probably continue in the near future due to rising age of the population. Closed methods of treatment have...