Histopathological Study of Malignant Bone Tumours in a Tertiary Care Centre in Karnataka, India
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 4
Abstract
Background: Although malignant bone tumours are infrequently encountered compared to the occurrence of other neoplastic lesions, they are of great significance because majority of them affect adolescents and young adults with a tendency of aggressive course. Morphological diagnosis of these tumours can be highly challenging. Objectives: 1. to know the incidence of malignant tumours of bone in this institute. 2. To study the histomorphological features of these lesions. 3. To classify these lesions by WHO classification and study the incidence of different lesions with respect to age, sex and site. Methodology: Biopsies and specimens received at the department of Pathology, KIMS, Hubli from July 2006 to June 20111 were subjected to routine fixation, processing and sectioning. Results: Out of the total 115 tumour and tumour like lesions of bone that were encountered during the study period, malignant bone tumours were 31 (26.9%), benign bone tumours 71 (61.73%), and tumour like lesions 13 (11.3%). Peak incidence of the malignant tumors was seen in third decade of life (34.7%). Osteosarcoma was the commonest malignant tumor (58%) followed by Ewing’s sarcoma (16.2%) and chondrosarcoma (9.6%). There were 3 cases of secondary tumors - one of renal cell carcinoma and the other two were adenocarcinomas of unknown primary. Conclusion: Malignant bone tumours form an important group of neoplastic lesions during the period of active growth spurt in adolescents and young adults. Adequate sampling of histopathological specimen with analysis of clinical details and radiological pictures can help in diagnosing the lesion with certainty.
Authors and Affiliations
Gayathri T.
Keywords
Related Articles
- EP ID EP467863
- DOI 10.21088/ijprp.2278.148X.6417.7
- Views 43
- Downloads 0
Spectrum of Cervical Lesions Detected by Pap Smear: An Experience from a Rural-Based Tertiary Care Teaching Hospital
Background: Routine screening test like Pap smear test can detect early changes in the cervical epithelial cells, thereby facilitating the appropriate management of the disease. The present study investigates the distrib...
A Study of Seminal Parameters in Infertile Men
Objective: To determine the prevalence of low sperm count (oligozoospermia) & azoospermia (absence of sperms) in seminal plasma infertile male & to assess the pattern & distribution of abnormal sperm parameters in infert...
Analysis of Cervical Pap Smears and Its Utilty in Screening for Premalignant Lesions in a Tertiary Care Instituition
Introduction: Cervical cancer is the leading cause of mortality and morbidity among women with nearly four lakh new cases diagnosed annually worldwide, of which 80 % cases are in developing nations. Cervical Pap smear is...
Spectrum of Testicular FNAC in Infertile Males : A Study of 50 Cases in a Tertiary Medical Centre in North India
Background: Testicular FNAC is a simple and an inexpensive method for evaluation of testicular pathology including inflammatory, non-neoplastic and neoplastic conditions and now has gained popularity as a diagnostic and...
VEGF: A Noble Immunohistochemical Marker in Diagnosis of Dysfunctional Uterine Bleeding
Background: Dysfunctional uterine bleeding (DUB) is characterized by abnormal bleeding that is unrelated to any identifiable cause. The aim of this study is to establish that, DUB is a disorder of angiogenesis by detecti...