HPV ASSOCIATION WITH CARCINOMA CERVIX, CLINICAL IMPLICATIONS AND PROGNOSTIC VALUE IN CARCINOMA CERVIX
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 2
Abstract
Aim and Objective- Cervix cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide. Some 99 per cent of cervical cancer cases are linked to genital infection with human papillomaviruses (HPVs). The clinicopathological parameters and response to radiotherapy varies with the genotypes of HPV. This study was aimed at association of HPV with cervical carcinoma and to evaluate the correlation of different HPV genotypes with parameters such as histological type, age at onset, clinical stage and response to radiotherapy in diagnosed cases of carcinoma cervix.HPV DNA was detected by Real time PCR technique in the cervical smears of 50 patients of FIGO stage- IIA to IIIB. Materials and Method -Association was then estimated between HPV genotypes and various clinicopathological parameters. External beam radiation with concurrent chemotherapy followed by intracavitary brachytherapy was delivered to all patients. Response to radiotherapy was then assessed according to different HPV genotypes. Chi Square test of significance was used for all the calculations.A total of 50 patients were analyzed. Results- HPV DNA sequences were detected in 84% of the specimens. Among HPV positive samples, HPV 16 and HPV 18 were found in 67% and 21 % of the samples respectively.Poorer response to radiotherapy was observed in the patients negative for HPV genotype or positive for HPV-18 genotype. No correlation was seen between HPV genotype and other clinicopathological parameters like age, stage, histopathological type. Conclusion- These data suggest that the HPV type present in cervical carcinoma is related to clinical behavior and response to radiotherapy.
Authors and Affiliations
Ratika Gupta, Pardeep Garg, Lajyadevi Goyal, Neerja Jindal,, Sapna Marcus, Raja psbanipal, HP Yadav
Keywords
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