Human papilloma virus and p53 protein expression in patients with laryngeal squamous celi carcinoma: correlation between human papilloma virus and p53 protein expression
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 3
Abstract
SUMMARY Purpose: The aim of this study was to determine the expression of p53 and prevalence of HPV infection in laryngeal squamous celt carcinoma, and to analyze relationship between HPV infection and P53 expression. Materia! and Method: The immunohistochemistry (IHC) staining was used to detect the HPV prevalence and P53 expression in 130 specimens of laryngeal squamous celt carcinoma. Results: P53 nuclear expression was detected in 83 (63.8%) out of 130 patients with laryngeal squamous celt carcinoma (LSCC). HPV was identified in 27.7% using IHC of patients with laryngeal squamous celt carcinoma. There was no statistically significant association between the presence of HPV and the epidemiological and clinicopathological features. There was no statisti-cally significant association between the presence of HPV and overall specific survival or P53 expression and overall specific survival. Statistical analysis revealed significant relationship between p53 expression and tumour N stage (p=0.02), clinical stage (0.4) and localization (p=0.01) and proved that p53 expression was frequently higher in patients with supraglottic localization and in patients with stage III + IV. Nuclear expression of p53 was detected in 25 (69.4%) out of 36 HPV positive specimens from patients with LSCC. There was no statistically significant correlation between p53 positive staining and HPV infection (x2 = 0.67; p=0.41) A multivariate analysis of survival showed that p53 expression and HPV infection was not an independent prognostic factor in laryngeal cancer Conclusions: In conclusion our observations in the current study suggest that the are no relationship between p53 mutation and HPV infection. P53 expression and or HPV presence are not an independent prognostic factor in patients with LSCC
Authors and Affiliations
Kamal Morshed, Marcin Szymański, Małgorzata Polz-Dacewicz, Marek Zadrożniak, Dorota Polz, Agnieszka Korolczuk, Agata Smoleń
Keywords
Related Articles
- EP ID EP52281
- DOI -
- Views 82
- Downloads 0
Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion
Introduction: In hypertrophied adenoid lymphocytes B make up about 60% all lymphocytes. When the lymphocytes B come in interaction with antigens this membranes signal be passed through their receptor (BCR) to interior of...
Wpływ wykonania kochleostomii na zachowanie słuchu – badania na modelu zwierzęcym
Introduction: To assess an effect of cochleostomy on hearing threshold in guinea pigs. Material and methods: The authors performed animal experiments using fi ve 3-month-old guinea pigs. Before experiment hearing thresho...
Role of adenotonsillectomy in OSAS children and behavioural disturbance
Aim: The main aim of this study was to assess the presence of behavioural disturbances in child with OSAS before and after adenotonsillectomy (AT). Background: In children adenotonsillar hypertrophy is associated with in...
Czy lekarze odbywający staż w zakresie laryngologii ujawniają swój udział w operacji podczas uzyskiwania zgody pacjenta na zabieg?
Cel: Zbadanie, w jakim stopniu lekarze odbywający staż z laryngologii ujawniają pacjentom fakt wzięcia udziału w operacji podczas uzyskiwania zgody pacjenta na zabieg.Wprowadzenie: Nie jest jasne, w jaki sposób stażyśc...
Zastosowanie bipolarnej termoterapii śródmiąższowej w leczeniu przerostów małżowin nosowych
Disturbance of nasal airflow occurs in about 30% of human population. Turbinate hypertrophy is frequently the base of many nasal obturative diseases. The aim of this study was to determine short- term and long term effec...