Human Serum Paraoxonase Activity in Patients with Type II Diabetes Mellitus as Compared to that of Control Subjects
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 9
Abstract
Diabetes is closely related to the development of coronary artery disease (CAD) and myocardial infarction (MI). The oxidative modification of low-density lipoprotein (LDL) in the artery wall is currently believed to be central to the pathogenesis of atherosclerosis. Oxidized LDL has also been shown to be cytotoxic to capillary endothelial cells. The inverse relationship between serum PON activity and the risk for atherosclerotic diseases suggests that PON hydrolytic activity on oxidized LDL may be related to its antiatherogenicity. Serum PON activity is decreased in subjects who have had a myocardial infarction and in subjects with type I and type II diabetes. In this study human serum paraoxonase activity in patients with type II diabetes mellitus were compared to that of control subjects. 100 patients and 30 controls were taken. The result of this study revealed that the PON activity of the patients of type 2 diabetes mellitus was lower than that of the controls. As PON is known to be an antioxidant, the decreased PON activity could be responsible for increased levels of ox-LDL in these patients with consequent development of diseases like myocardial infarction and hypertension.
Authors and Affiliations
Dr. Ashita Sharma, Dr. Gurmanpreet . , Dr. Neeru Bhaskar
Keywords
Related Articles
- EP ID EP480213
- DOI -
- Views 48
- Downloads 0
Azithromycin: Not Just an Antibiotic Anymore
Azithromycin (AZI), prototype of a novel class of macrolide named azalide,is a congener of erythromycin . Macrolides including azithromycin are used for wide range of infections such as upper respiratory tract infections...
Mutational analysis of Erythropoietin gene and its enhancer in anemic cancer patients
Abstract: Erythropoietin (Epo) is a crucial hormone which binds to a cell surface receptor, triggers a set of downstream genes and plays a role in the feedback mechanism involved in correcting cellular hypoxic situation...
The Madura Foot: A Case of Eumycotic Mycetoma on Histopathology
Madura foot or mycetoma is a chronic granulomatous disease characterized by chronic infection of skin and subcutaneous tissues, caused by true fungi (eumycetoma) or by filamentous bacteria (actinomycetoma). It is endemic...
FNAC and FNNAC in Thyroid Lesions: A Comparative Study
Abstract: To compare the two techniques namely fine needle aspiration and fine needle non aspiration cytology in thyroid lesions. The present study was undertaken to compare the two techniques namely fine needle aspirati...
Study on Bone Marrow Profile of Patients with Pancytopenia in a Tertiary Care Centre
Abstract: Pancytopenia is a common haematological entity that is characterized by the simultaneous presence of anemia, leukopenia and thrombocytopenia. A multitude of disorder primarily or secondarily affecting the bone...