Hydrogels based on ionically and covalently crosslinked alginates
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2015, Vol 18, Issue 132
Abstract
In this work a method of formation of hydrogel beads with increased mechanical durability is presented. Sodium alginate in the form of hydrogel beads was modified by ionic and covalent crosslinking. The crosslinking was achieved in two steps. In the first step, sodium alginate was ionically crosslinked by the ionic exchange of monovalent sodium cations with bivalent calcium cations. Different forms of the crosslinked alginate were obtained depending on the calcium chloride concentration. The forms varied from shapeless gel to hard agglomerated spheres. To increase mechanical durability of the ionically crosslinked alginate it was subjected to the reaction with epichlorohydrin. The reaction allowed to introduce covalent bridges between alginate chains. For additional reinforcement the crosslinked beads of alginate were modified with cellulose nanofibers. Dependence of water absorption in the dry samples on the crosslinking level was observed. Morphology of the beads was observed with the use of scanning electron microscopy. Calcium ions distribution in the samples was evaluated by energy dispersive spectroscopy analysis. In vitro degradation of the crosslinked alginates was also investigated.
Authors and Affiliations
J. Walczak
Keywords
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