HYPEROSMOLALITY ALTERS MACROPHAGE SYNTHESIS AND REGULATION; ROLE OF PHOSPHOLIPASE C ENZYMES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 1
Abstract
High NaCl stimulates activity of the osmoprotective transcription factor TonEBP/OREBP by enhancing its phosphorylation, transactivating ability, and localization to the nucleus. PLC γ plays an important role in these mechanisms. On the other hand, macrophages play important roles in both innate and adaptive immune responses. One major function of macrophages is to monitor their environment for invading pathogens like bacteria or viruses and consequent elimination by phagocytosis. In addition, phagocytosing macrophages are essential for the clearance of apoptotic cells and cell debris. Foreign antigens are identified and internalized by pattern-recognition receptors on the cell surface, including scavenger receptors and Toll-like receptors. This review examines the influence of NaCl induced hyperosmolality and the role of Phospholipase C (PLC) in macrophage synthesis and regulation.
Authors and Affiliations
Manoj G Tyagi| Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu
Keywords
Related Articles
- EP ID EP3480
- DOI -
- Views 306
- Downloads 18
Transdermal Delivery of Bisoprolol Hemifumarate
The aim of this study was to formulate and evaluate the administration of bisoprolol hemifumarate (BH) using transdermal delivery systems. The following formulae were prepared as a reservoir to be used in batch formula...
SEROPREVALENCE OF HEPATITIS C VIRUS AMONG HEPATITIS B VIRUS POSITIVE PATIENTS ATTENDING TO TALODI HOSPITAL, SOUTH KORDOFAN, STATE, SUDAN.
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic confection is a fairly frequent occurrence, especial...
RP-HPLC assay method development and validation of ketorolac and olopatidine in opthalmic liquid dosage forms
A simple reverse phase high performance liquid chromatographic assay method was developed and validated for the simultaneous estimation of Ketorolac and olopatadine in ophthalmic liquid dosage forms. The chromatographic...
To Evaluate the Clinical Efficacy of Combination of Low Dose Bisoprolol Fumarate and Low Dose Hydrochlorothiazide with Bisoprolol Alone in Stage I and II Hypertension
OBJECTIVE: Control of hypertension by the use of low dose combination therapy is associated with greater efficacy, less side effects and higher response rates as the result of complementary mechanisms of antihypertensiv...
COMPARATIVE IN VITRO ANALYSIS OF PHYSICOCHEMICAL PROPERTIES OF SOME ACECLOFENAC GENERIC TABLETS MARKETED IN BANGLADESH
Aceclofenac is a non-steroidal anti-inflammatory drug analog of diclofenac and works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandin (PG) and accountable for pain, swe...