Hypoglycemic and antihyperglycemic activities of Bauhinia thonningii (caesalpiniaceae) fruit in rat wistar
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 1
Abstract
Diabetes is a metabolic disease characterized by chronic hyperglycemia resulting from a defect in the secretion of insulin and / or the action of this hormone. The therapeutic management of this pathology in most developing countries is costly given the low purchasing power of the populations. The traditional African pharmacopoeia offers an alternative to synthetic antidiabetics. The objective of this study is to demonstrate the hypoglycaemic and anti-hyperglycemic properties of Bauhinia thonningii (Caesalpiniaceae) fruits in rats. The aqueous extract of the fruits of this plant was administered orally to different batches of normoglycemic rats and then to hyperglycemic rats at doses of 25, 50, 100 and 150 mg / kg body weight (bw). The results of this study showed that the fruits of Bauhinia thonningi possess hypoglycaemic (p = 0.0356) and anti-hyperglycemic (p <0.0001) properties.
Authors and Affiliations
Bédou Kouassi Denis, Baba O Zeine Mohamed Anouar Sadat, Konkon Ndri Gilles, Edjeme-Aké angèle, Djaman Allico Joseph, N’guessan Jean-David
Keywords
Related Articles
- EP ID EP33501
- DOI -
- Views 360
- Downloads 0
FORMULATION AND IN-VITRO EVALUATION OF TERBUTALINE SULPHATE SUSTAINED RELEASE TABLETS
Sustain release formulation maintain a constant level plasma concentration of drug so that multiple and night dosing can be avoided. Terbutaline sulphate is a β2 stimulant drug which is having a very short half life of...
Antimicrobial activity of Vitex leucoxylon, Vitex negundo and Vitex trifolia
In the present study, an attempt was made to investigate the anti-bacterial activity of Vitex leuocoxylon, Vitex negundo and Vitex trifolia. The crude drug powder extracts of the leaves of the above plants were taken f...
An Introduction to Malt Production and Malt Mixing
Production of malt is a complicated technological method including soaking, sprouting and drying of sprouted malt in controlled conditions of temperature and moisture. Constant development in developing countries like I...
The study of anti-diabetic activity of aqueous extract of root of Gynandropsis gynandra in diabetic rats
It has been planned to explore the hypoglycaemic and antihyperglycaemic activity of aqueous extract of root of Gynandropsis gynandra herb in normal and diabetic rats.The extract was evaluated for its specific physical...
Development and Validation of Related Substances Method for Febuxostat Tablets by RP-HPLC
The present paper describes about highly sensitive, linear, precise, rugged, accurate and robust RP-HPLC method for determination of related substances present in Febuxostat tablets. Chromatographic separation with sep...