HYPOLIPIDEMIC ACTIVITY OF ALOE VERA IN HYPERLIPIDEMIC RATS
Journal Title: International Journal of Pharmacognosy - Year 2016, Vol 3, Issue 4
Abstract
The hypolipidemic activity of Aloe Vera (Family: Liliaceae) extract has been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of triton WR-1339 (400mg/kg, b.w.) intraperitonially in rats. Feeding with Aloe Vera extract at the dose of 500 mg/ kg, b.w. exerted significant lipid lowering effect as assessed by the reversal of plasma levels of total cholesterol (TC), phospholipids (PL), triglyceride (TG) and reactivation of post heparin lipolytic activity (PHLA). In the chronic model, hyperlipidemia was induced by feeding with cholesterol rich- HFD in rats. The treatment with seeds extract of Aloe Vera (500 mg/ kg b.w) simultaneously for 15 days also caused lowering of lipid levels in plasma and liver following reactivation of plasma post heparin lipolytic activity and hepatic lipoprotein lipase activity in animals. The hypolipidemic activity of Aloe Vera was compared with a standard drug guggulipid (200 mg/ kg, b.w.) in both models.
Authors and Affiliations
Prabha Verma et al.
Keywords
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