HYPOLIPIDEMIC ACTIVITY OF LUFFA AEGIPTIACA FRUITS IN CHOLESTEROL FED HYPERCHOLESTEROLEMIC RABBITS
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 1
Abstract
The methanolic extract of Luffa aegiptiaca fruits were investigated for their possible hypolipidemic effect on hypercholesterolemia induced Newzealand white rabbits by feeding the animals with normal diet supplemented with 1% cholesterol and 10% ground nut oil for 8 weeks. Rabbits with normal diet and hypercholesterolemic diets through out the experiment were used as negative and positive control respectively. There was a significant increase in the weight of hypercholesterolemic rabbits when compared to normal control. Methanolic extract of Luffa aegiptiaca fruits significantly reduced serum total cholesterol of hypercholesterolemic rabbits by 29%, Triglycerides by 52%, LDL Cholesterol by 22% and it also increased serum HDL by 38%. This observation demonstrated that Luffa aegiptiaca fruits have strong hypolipedemic effect which compared with improved HDL / LDL ratio is an indication of the possible use of this fruits in the treatment of the diseases associated with hyperlipidemia such as Ishcaemic heart diseases and arteriosclerosis.
Authors and Affiliations
Abdul Hameed Thayyil , M. K. M. Surulivel , Mohammed. Fazil Ahmed , G. Shaik Shafee Ahamed , Aboobacker Sidheeq , Asif rasheed , Mohammed Ibrahim
Keywords
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