HYPOLIPIDEMIC ACTIVITY OF LUFFA AEGIPTIACA FRUITS IN CHOLESTEROL FED HYPERCHOLESTEROLEMIC RABBITS
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 1
Abstract
The methanolic extract of Luffa aegiptiaca fruits were investigated for their possible hypolipidemic effect on hypercholesterolemia induced Newzealand white rabbits by feeding the animals with normal diet supplemented with 1% cholesterol and 10% ground nut oil for 8 weeks. Rabbits with normal diet and hypercholesterolemic diets through out the experiment were used as negative and positive control respectively. There was a significant increase in the weight of hypercholesterolemic rabbits when compared to normal control. Methanolic extract of Luffa aegiptiaca fruits significantly reduced serum total cholesterol of hypercholesterolemic rabbits by 29%, Triglycerides by 52%, LDL Cholesterol by 22% and it also increased serum HDL by 38%. This observation demonstrated that Luffa aegiptiaca fruits have strong hypolipedemic effect which compared with improved HDL / LDL ratio is an indication of the possible use of this fruits in the treatment of the diseases associated with hyperlipidemia such as Ishcaemic heart diseases and arteriosclerosis.
Authors and Affiliations
Abdul Hameed Thayyil , M. K. M. Surulivel , Mohammed. Fazil Ahmed , G. Shaik Shafee Ahamed , Aboobacker Sidheeq , Asif rasheed , Mohammed Ibrahim
Keywords
Related Articles
- EP ID EP97964
- DOI -
- Views 127
- Downloads 0
ANALYSIS OF ACHYRANTHES ASPERA (ASH) ON REPRODUCTIVE FITNESS OF DROSOPHILA MELANOGASTER.
Drosophila is a suitable model organism to test phytochemicals. The objective of our study was to explore the potential of Achyranthes aspera on reproductive fitness of Drosophila melanogaster using larval and adult...
EFFECT OF ESSENTIAL OIL OF CITRUS RETICULATA ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN INDUCED DIABETIC RATS
In the present study, the essential oil of Citrus reticulata is investigated for anti-diabetic activity. The present study was planned to elucidate hypoglycemic effect of essential oil of Citrus reticulata and its...
AYUR-INFORMATICS: BLOCKING THE TRANSLATION PATHWAY OF FUMARATE HYDRATASE MUTATION GENE BY RNAI TECHNIQUE AND ESTABLISHING AN AYURVEDIC REMEDY FOR UTERINE FIBROIDS
Fumarate hydratase precursor (mutation) protein of Homo sapiens was taken. Homology modeling studies were done and 3D structure of FH protein was modelled. Ayurvedic herbs Aloe vera, Commiphora mukul, Asparagus r...
ANTIBACTERIAL ACTIVITY OF STEM AND ROOT EXTRACTS OF Avicennia officinalis L
Extracts of stem and root of Avicennia officinalis L. were prepared in hexane, benzene, ethyl acetate, acetone, methanol and ethanol, and their antibacterial activity was evaluated against Escherichia coli MTC...
EFFECT OF POLYMER AND GAS FORMING AGENT ON FLOATING DRUG DELIVERY OF TRAMADOL HYDROCHLORIDE USING RESPONSE SURFACE METHODOLOGY: IN VITRO AND IN VIVO EVALUATION
Tramadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 5.5 hours and oral dose is 50 to 100 mg every 4...