Hypouricemia in type 2 diabetes mellitus without nephropathy: A case control study
Journal Title: IP International Journal of Maxillofacial Imaging - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Some previous studies and our recent study had shown low serum uric acid (UA) in Diabetic patients compared to Non diabetics and it was suggested that low serum UA levels in Diabetics are probably due to uricosuric effect of urinary Glucose. This study was conducted to have an insight regarding the pathophysiology of low serum UA levels in Diabetics. Materials And Methods:Fasting blood glucose(FBG) , Post lunch blood glucose(PLBG), serum UA and 24 hr urinary excretion were estimated in Type 2 Diabetics without nephropathy (Cases) and in Nondiabetic inpatients(Controls) who got admitted into various Departments of KIMS hospital. The comparison of serum UA and 24hr urinary excretion between cases and controls and correlation between 24 hr urinary excretion, FBG and serum UA in cases was tested using SPSS 19 version. Result: Serum UA Mean is low in Diabetics compared to Non diabetics and this difference is significant whereas 24 hr urinary excretion is significantly higher in Diabetics compared to Nondiabetics. Significant negative association between FBG and serum UA and positive association between 24hr urinary UA and FBG and negative association of 24 hr urinary excretion with serum UA in Diabetics which is nonsignificant. Summary and Conclusions:At high concentrations of FBG there is increase in 24 hr urinary excretion providing an objective evidence to hypothesis that low UA levels in diabetics are probably due to inhibition of UA reabsorption in the proximal convoluted tubule of kidney by glucose.
Authors and Affiliations
Bindu Pavani. CH, Shruti Mohanty, Archana A. Dharwadkar
Keywords
Related Articles
- EP ID EP472719
- DOI 10.18231/2394-6377.2018.0041
- Views 74
- Downloads 0
Degradation of Spectrin and band 3 protein
Oxygen free radicals generated during radiation injury damage human erythrocyte membrane proteins including spectrin and band 3 protein. Results show an appreciable degree of spectrin and band 3 protein loss of about 55-...
Study of serum Vitamin D in Type II diabetes mellitus in Civil Hospital Ahmedabad
Introduction: Type-II diabetes is one of the most common non-communicable chronic disease and Vitamin D deficiency is also considered a public health problem around the world. As Vitamin D deficiency influence the insuli...
Correlation of trace elements (serum zinc and copper) in type 2 diabetic patients with and without complications
Introduction: Type 2 diabetes mellitus (DM) is supposed to be associated with alteration in the serum levels of trace elements. Conversely, research also suggests that imbalances of specific elements associated with the...
Establishment of reference intervals of thyroid function test in healthy individuals
Aim: The central role of the laboratory is to aid the clinician, in interpreting observed values, by providing relevant reference values. To prevent ambiguities inherent in the term normal values, a laboratory should est...
Evaluation of the frontal sinuses dimensions in sex estimation among a sample of adult Kashmiri population using multidetector computed tomography
Introduction Aim of the present study is to determine gender using morphometric measurements on the frontal sinuses MDCT scanMaterials and Methods The study included 100 subjects 50 males and 50 females For each particip...