IMMUNOHISTOCHEMICAL CORRELATION OF E-CADHERIN EXPRESSION WITH DIFFERENTIATION GRADE OF INVASIVE DUCTAL CARCINOMA IN SUDANESE FEMALES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 1
Abstract
Background: E-cadherin is a cell surface protein involved in cell adhesion, present in normal breast epithelium, and in certain breast carcinoma. The utility of the E-cadherin immunohistochemical stain to distinguish between lobular and ductal carcinomas that are difficult to classify by morphologic features alone has been well-documented. Objectives: this study aimed to investigate E-Cadherin expression in invasive ductal carcinoma of different grades of differentiation and correlated the expression patterns with their histological type and grade using immunohistochemical staining. Materials and methods: Formalin fixed-Paraffin embedded blocks from 50 female patients with invasive ductal carcinoma were used, immunohistochemistry staining for E-cadherin was performed and the intensity and extension of E-Cadherin immunoreactivity was evaluated as normal or loss of expression in all 50 cases of different grades invasive ductal carcinoma and correlated with their histological type and grade. Results: 72% of cases showed normal expression of E-cadherin and 28% had loss of expression, we found that loss of expression of E-cadherin increase with increase of tumor grade from 2% for Grade 1 to 16% in Grade 3 tumor. But statistical analysis showed no significant association p value (0.920). Conclusion: we conclude that there is no statistical significant Loss of E.cadherin expression in invasive ductal carcinoma grades in Sudanese patients.
Authors and Affiliations
Ayda Dirar Abdellatif Osman*| MSc, Department of Histopathology & Cytology Faculty of medical laboratory sciences Al-Neelain University, Khartoum, Sudan., Elsadig. A. Adam| MD, Department of pathology Al-Ribat National University, Khartoum, Sudan., Hadia. Mohammed. Abdalla. Abdalrhman| MSc, Department of Histopathology & Cytology Faculty of medical laboratory sciences Al-Neelain University, Khartoum, Sudan., Namareg. E. Afadul| MSc, Department of Histopathology & Cytology Faculty of medical laboratory sciences Al-Neelain University, Khartoum, Sudan., Fathelrahman. M. A. Ibrahim| Postgraduate Coordinator, Department of Histopathology & Cytology Faculty of medical laboratory sciences Al-Neelain University, Khartoum, Sudan.
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