Immunohistochemical Expression of JAK-P, STAT3 & BCL-2 in Oral Squamous Cell Carcinoma with and Without Lymph Node Metastasis And in Verrucous Carcinoma
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Objective: Inappropriate activation of JAK/STAT pathway and BCL-2 occurs with high frequency in human cancers and is associated with cancer cell survival and proliferation. However, its role in oral squamous cell carcinoma (OSCC) with and without lymph node metastasis and in verrucous carcinoma (VC) is still debatable. Methods: By immunohistochemistry, we analysed the expression of phosphorylated JAK-2 (pJAK-2), STAT-3 and BCL-2 in resection specimens of OSCC with and without lymph node metastasis (30 cases each), in Verrucous carcinoma (30 cases) and in normal mucosal margins (20 cases). We also compared their respective immunohistochemical expression between OSCC, VC and in normal oral mucosa. Results: We found that pJAK-2 and STAT-3 expression was not detectable in normal mucosa however JAK/STAT pathway was involved in 66% of OSCC and 23% of Verrucous carcinoma.Bcl-2 expression was noted in 23% of OSCC and 6.6% of Verrucous carcinoma. Conclusion: Oral cancer is the third most common in India with most common age of presentation being 4th-5th decade. Immunoexpression of bcl-2 revealed a bad prognostic marker as it showed inverse correlation with tumor differentiation in OSCC. Majority of these tumors show involvement of JAK- STAT pathway in the tumor development and progression which accounts for 66.6% in OSCC and 23% in VC. Further clinical trials and molecularly targeted research on JAK-P, STAT3 and BCL-2 is required to improve the treatment, patient care and prognosis as it is the major pathway involved in development of OSCC.
Authors and Affiliations
Nishtha Khera, MK Singh, Sudheer Arava
Keywords
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- EP ID EP548759
- DOI 10.21276/ijmrp.2017.3.6.032
- Views 84
- Downloads 0
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