Immunological factors of cardiovascular risk (TNF-α) depending on various hemodynamic forms of arterial hypertension in adolescents
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
119 children aged 12-17 years with the stable and labile forms of arterial hypertension (AH) and prehypertension hospitalized to cardiopulmonary department due to ambulatory single-measured blood pressure (BP) elevation were observed. The level of TNF-α in adolescents with different forms of AH and prehypertension as well as the correlation of this marker with other cardiovascular risk factors was determined. There was a significant increase in the mean value (9.50±0.54 pg/ml) and frequency (45.6%) of increase of TNF-α level in the group of children with AH compared with the group of children with normotension (6.43±0,64 pg/ml and 12.5% respectively). There is shown a tendency to increase of TNF-α levels, depending on the degree of stabilization of AH with the highest level of proinflammatory cytokines of TNF-α in the group of children with stable systolic BP. The positive correlation of TNF-α with the daily BP monitoring indicators, especially with the level of diastolic BP and its variability at night was revealed.
Authors and Affiliations
T. A. Gayduk, L. R. Shostakovych-Koretska, O. I. Gayduk
Keywords
Related Articles
- EP ID EP319949
- DOI 10.26641/2307-0404.2018.1(part2).126938
- Views 81
- Downloads 0
The role of tumor molecular subtypes in formation of personalized approach to the theatment of the breast cancer
Extreme heterogeneity of breast cancer (BC) is considered to be one of the reasons that affects the success of treatment. According to current classifications, there are 4 molecular subtypes (MS). The basis for subtypes...
Influence of gel bentonite on physiological indicators of the white laboratory mice
The evaluation of the effect of lifelong usage of sodium form of gel bentonite on some physiological parameters of mice (body weight, feed and water intake, general condition, change in coordination of movements, state o...
The use of trypsin-like blood activity as a marker of pulmonary fibrosis severity
Purpose – to determine changes in the trypsin-like blood activity and its relationship with acute phase indices of inflammation in patients with pulmonary fibrosis (PF) as a marker of course severity and prognosis of the...
Dependence of cytokinemia on the clinical course of chronic obstructive pulmonary disease combined with hypertension
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease. The prevalence of COPD continues to increase steadily. 90% of patients with COPD have at least one comorbid pathology. Among concomitan...
Comparative evaluation of genetic risk models of reproductive disorders caused by MTHFR, MTRR, MTR1 gene polymorphism
The scientific literature presents contradictory data about influence of folate metabolism genes polymorphism on development of risk of reproductive disorders. The aim of the study was to determine the role of MTHFR, MTR...