Immunological indicators in HIV/AIDS-infected patients with viral skin defects
Journal Title: Український журнал дерматології, венерології, косметології - Year 2019, Vol 0, Issue 1
Abstract
Objective — to study a number of immunological indices in HIV/AIDS-infected patients with viral skin lesions. Materials and methods. Our follow-up involved 40 cases with skin pathology against a background of HIV/AIDS infection at the age of 18—53 years (20 men and 20 women). The patients had viral pathology (20 cases with recurrent herpes simplex and 20 ones with chronic ulcerative herpes simplex). There were 25 patients with HIV infection stage II, and 15 — with stage III. Immunological studies were carried out before the treatment and 2 months after it. Together with antiretroviral therapy (ART), the treatment in cases of chronic ulcerative herpes and recurrent herpes simplex included acyclovir, 400 mg 5 times a day, and Cidipol solution externally. Group 1 received ART and antiviral therapy according to the protocol. Group 2 received ART, antiviral medicines and Cidipol solution externally. Results and discussion. The study showed that after 2 months of complex treatment with Cidipol in patients of the group 2, there was a significant (p < 0.01) increase in CD3+-cells (p < 0.01), the relative number of CD3+-cells tended to increase. The levels of CD3–CD16++CD56+-cells and phagocytic activity of neutrophils also tended to increase. In addition, a significant reduction and approximation to the normal values of Ig and heterophilic hemolysin levels were established (p < 0.05 and p < 0.01, respectively). The results of the study indicate a pronounced decrease to the normal values of the level of activity of the complement system. By the number of lymphocytotoxic autoantibodies there was a tendency to decrease. Patients in the group 1 after 2 months of observation showed a tendency to the increase of the relative and absolute number of CD3+-cells. The relative value of CD3–CD16++CD56+-cells also changed in the direction of their increase. On the part of the humoral immune system, attention was paid to the lack of normalization of elevated levels of IgA and a tendency to increase IgM and IgG levels. There was also a tendency to the increase of the level of heterophilic hemolysins. Conclusions. Studies of the above relationships in cases of viral lesions in HIV/AIDS-infected patients will make it possible to fully understand the cytokine response, thereby enabling us to increase the efficacy of the given therapy and prevention of viral dermatoses in such patients.
Authors and Affiliations
L. O. Kutsevlyak, A. M. Dashchuk
Keywords
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- EP ID EP577089
- DOI 10.30978/UJDVK2019-1-15
- Views 102
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