Impact of administration of folic acid on selected indicators of inflammation in patients with primary arterial hypertension
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2015, Vol 69, Issue 0
Abstract
The results of epidemiological and clinical tests have shown that in patients with primary arterial hypertension, a chronic mild inflammation develops. The purpose of the study was to determine whether administration of folic acid to patients with primary arterial hypertension influences concentrations of indicators of inflammation: hsCRP, sICAM-1 and sVCAM-1. The examination was carried out in 41 patients with primary arterial hypertension, aged 19–65 (21 men and 20 women), without complications of hypertension and/or coexisting diseases. The examined patients were administered 15 mg of folic acid once a day for 45 days. Before and after administration of folic acid, concentrations of folic acid, homocysteine, hsCRP, sICAM-1 and sVCAM-1 in serum were assessed. Concentrations of folic acid and homocysteine were determined using the immunoenzymatic method (Abbott) on an AxSYM analyzer. The level of C-reactive protein (CRP) was determined with an ultra-sensitive turbidimetric assay on a Dimension analyzer (Siemens). Next, concentrations of adhesion particles sICAM-1 and sVCAM-1 were assessed with the ELISA technique (R&D). After the administration of folic acid in patients with primary arterial hypertension, a significant decrease in median concentrations of homocysteine in blood was observed. Simultaneously, the median hsCRP, ICAM-1 and VCAM-1 concentrations in serum in patients with primary arterial hypertension were significantly reduced.Administration of folic acid to persons with primary arterial hypertension in a dose of 15 mg/ day for 45 days caused a decrease in the concentration of homocysteine in serum. That could indirectly result in the decrease in concentrations of the indicators of inflammation (hsCRP, ICAM-1 and VCAM-1), as it is apparent from previous studies that hyperhomocysteinemia stimulates the synthesis of CRP and the expression of adhesion molecules.
Authors and Affiliations
Aleksandra Baszczuk, Zygmunt Kopczyński, Jarosław Kopczyński, Maciej Cymerys, Anna Thielemann, Lena Bielawska
Keywords
Related Articles
- EP ID EP67651
- DOI -
- Views 141
- Downloads 0
Udział białek błony zewnętrznej we wrażliwości bakterii na nanosrebro
Przedmiotem opracowania jest analiza udziału białek błony zewnętrznej we wrażliwości bakterii Gram‑ujemnych na nanomateriały srebra. Mechanizm oddziaływania srebra z komórką bakterii najdokładniej opisano dla tej grupy m...
Rola greliny i leptyny w regulacji metabolizmu węglowodanów. Część II. Leptyna
Leptyna jest wytwarzana przez dojrzałe adipocyty. Jej ilość dodatnio koreluje z ilością tkanki tłuszczowej. Leptyna odgrywa główną rolę w utrzymywaniu masy ciała oraz homeostazy glukozy. Jest transportowana poprzez barie...
Neonatal Fc receptor (FcRn) – not only transporter of maternal IgG
The neonatal Fc receptor, (FcRn) is a transmembrane, heterodimeric glycoprotein with a structure similar to MHC class I molecules. In contrast to MHC class I antigens, FcRn does not bind to peptides (antigens) but intera...
Systemic contact dermatitis
Systemic contact dermatitis (SCD) is a skin inflammation occurring in a patient after systemic administration of a hapten, which previously caused an allergic contact skin reaction in the same person. Most frequently, hy...
Antagoniści receptorów endotelinowych (ERA) – krótka charakterystyka nowej grupy leków
Endoteliny – śródbłonkowe peptydy, których właściwości są badane od ponad 25 lat, odgrywająszczególną rolę w patofizjologii wielu chorób, głównie obejmujących układ sercowo-naczyniowy.Najlepiej dotychczas zbadana endotel...