Bacterial, viral and fungal infections in primary immunodeficiency patients
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue
Abstract
Primary immunodeficiency diseases (PIDs) are genetic based disorders which lead to the dysfunction of the immune system. There are persistent and recurrent infections within PID patient due to cellular and humoral immunity impairment. The most common infections are caused by Salmonella Enteritidis, Shigella flexneri, Mycobacterium avium complex, Toxoplasma gondii, CMV, Candida albicans, Cryptococcus neoformans or Pneumocystis jiroveci. These infections have a severe course of disease with limited treatment in a conventional way. Full patient recovery after intensive and long-term therapy is often impossible. Viral infections in PID patients are equally frequent. The incidences of Herpesviridae and HCV infections are the same for PID patients and healthy people. However, the infections may have worse course of disease and leave more destruction in the body. Enteroviral infections occur despite the antibodies supplementation; they spread spontaneously throughout the body, also affecting the central nervous system. Skin, nails and mucous membranes infections are equally persistent problems caused by fungi, mainly Candida genus. Infections with these pathogens are often accompanied by hormonal disorders and immunosuppressive therapy. Sepsis and mixed infections are definitely the most dangerous for patients with infections. Infections occur most often in the first years of the child’s life, when the body has not developed yet a fully functioning immunity system. The diagnosis of PNO in infants may be difficult due to the presence of antibodies from mother and the similarity of the symptoms of infectious diseases and common infections.<br/><br/>
Authors and Affiliations
Piotr Naporowski, Danuta Witkowska, Aleksandra Lewandowicz-Uszyńska, Andrzej Gamian
Keywords
Related Articles
- EP ID EP343207
- DOI 10.5604/01.3001.0012.1734
- Views 162
- Downloads 0
Prozdrowotne właściwości pektyn
Pektyny to heteropolisacharydy pozyskiwane na skalę przemysłową z roślinnych ścian komórkowych, wykorzystywane powszechnie jako czynnik żelujący w produkcji dżemów i galaretek oraz jako stabilizator napojów mlecznych i o...
New cytochrome P450 isoforms as cancer biomarkers and targets for chemopreventive and chemotherapeutic agents
Cytochromes P450 (P450) are a multigene family of enzymes possessing a central role in the oxidative metabolism of a wide range of xenobiotics, including anticancer drugs, and endogenous compounds. The activity of differ...
Role of prometastatic factors in gastric cancer development
The second half of the 20th century has seen a sharp worldwide decline in both the incidence and mortality of gastric cancer. Despite this, gastric cancer is the most common cause of mortality in the world. It is closely...
Reakcja nadwrażliwości kontaktowej Tc1 zależna, jej mechanizm i regulacja
Reakcja nadwrażliwości kontaktowej (CHS) na hapteny jest klasycznym przykładem odpowiedzi komórkowej. W fazie efektorowej CHS można wyróżnić dwa kolejno występujące po sobie etapy: fazę wczesną występującą już dwie godzi...
Proteins of human milk involved in immunological processes
Human milk contains a lot of components (i.e. proteins, carbohydrates, lipids, inorganic elements) which provide basic nutrients for infants during the first period of their lives. Qualitative composition of milk compone...