Impact of High EGCG Consumption on Mouse Liver
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 2
Abstract
Tea is one of the most popular beverages especially among Middle East countries. Epigallocatechin 3-gallate (EGCG), the principal component of green tea is known to have many beneficial effects in therapeutic doses. However, higher doses of EGCG may have a damaging impact on liver. This study was initiated to explore the effects of high doses of EGCG alone and under predisposing factors. One of these predisposing factors is fever that can be induced by lipopolysaccharide (LPS). Mice (ND4) were given single or multiple intragastric (IG) doses of EGCG 1500 mg/kg and(LPS) was injected intraperitoneal (IP) as a single dose of 6 mg/kg. Histopathological examination of liver was done and survival rates of animals were observed and statistically analyzed. A single high IG dose of EGCG alone did not show liver toxicity, while combination of a single dose of EGCG with a single dose of LPS, initiated liver toxicity as observed on histopathology. Repeated administration of high IG doses of EGCG without LPS showed mortality among treated mice; but mortality was increased under the influence of LPS. It can be concluded from this study that administration of high doses of EGCG alone can initiate liver toxicity. However, under febrile condition (induced by LPS), this toxicity can lead to increased mortality.
Authors and Affiliations
Ibrahim Ghalib Saleh| National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.-Departments of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt., Zulfiqar Ali| National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Naohito Abe| National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Mohamed F. Abd-Ellah| Departments of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt., Ikhlas A. Khan| National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.-Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA., Mohammad K. Ashfaq*| Thad Cochran Research Center, School of Pharmacy, University of Mississippi, Room 2047, University, MS 38677, USA.-National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
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