Impact of Kisspeptin on Prematur Puberty in Obese Girls
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Kisspeptin is a peptide hormone that appears to play a major role in the regulation of GnRH secretion,the researchaims to study the relationship between obesity and premature puberty touched by influence of kisspeptin concentration. The study was included 150girls and women divided into three groups. first group include fifty girls before menses with age range (9 -12years), twenty five girls were normal weight, the rest were obese girls .Second group with the same division system but these fifty women have normal menstrual cycle with age range (25 -45 years).Third group with age range (50 -60 years) after menopause age also divided into normal weight women and obese women. Hormones investigations included serum kisspeptin,leptin and IGF-1 were determined by ELISA.BMI was determined by anthrometeric mesurments. The mean (± SD) value of serum kisspeptin level of obese girls was highly significantly increased (16·83 ± 12·4 pmol/l ,p=0.001) in comparison to that of normal weight girls with same age range (8·99 ± 4·10 pmol/l) ,same highly significant findings was found with serum leptin and IGF-1 of obese girls ( 25.7 ± 3.8 ng/ml ,10.22± 2.50 pg/ml, 170 ±9.95 ng ml consequently) but serum Estadiol shows no significant difference between these two groups. Serum kisspeptin in obese girls before menses show positive significant correlation with serum leptin, Estradiol and IGF-1(r=0.45, p= o.o1), (0.40, P=0.01), (r= 0.39, p= 0.01) consequently. Despite that the mean of serum leptin of obese female with regular menses (28.7± 3.54 ng/ml) was significantly higher than that of normal weight female with regular menses (19.5± 3.4 ng/ml ),their serum kisspeptin ,estradiol and IGF-1 didn't differ significantly. Serum kisspeptin level of obese women after menopause was highly significantly increased (44.39± 4.3 pmol/l, p=0.001) in comparison to that of normal weight women (30.76 ±3.80 pmol/l), same significant findings was found with serum leptin and Estradiol of obese women (28.9 ± 5.44 ng/ml, 20.33 ± 4.22 pg/ml; consequently) In conclusion, the activity of serum kisspeptin (by other means the activity of kiss-1 neurons) increase with obesity, consequently the reproductive hormone kisspeptin tiger the premature puberty in obese girls in response to the effect of leptin
Authors and Affiliations
Dr. Maysaa Jalal Majeed, Dr. Manal Kamal, Shifaa Jameel Ibrahim, Dr. Ehsan K. Abass, Kawlha Ahamed
Keywords
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- EP ID EP254146
- DOI 10.9790/0853-1609011619
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