IMPROVING THE SOLUBILITY OF ANTIHELMINTIC DRUG BY SOLID DISPERSIONS AND INCLUSION COMPLEXES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Fenbendazole is an Antihelmintic drug (BCS class 2) and poorly soluble in water. Fenbendazole is used as a model drug. This study was conducted to enhance the bioavailability by increasing the aqueous solubility of Fenbendazole. The solid dispersions were prepared with polyvinylpyrrolidone K-25 (PVP K25) and Urea, Inclusion complexes with beta-cyclodextrin (BCD). Solid dispersions and inclusion complexes are prepared by Kneading and Solvent evaporation methods using different drug-polymer ratio like 1:2, 1:4and 1:6. The prepared formulations were characterized for FTIR, drug content, Phase solubility, percent yield and in vitro release studies followed by various release kinetics. The drug content uniformity was found to be good in all formulations. Kinetic profile showed good linearity with first order i.e. exhibiting concentration dependent release of drug. The result indicated that the solubility and dissolution rates of all formulation were significantly increased by solid dispersions and cyclodextrin complexes when compare to pure drug. Dissolution of the pure drug more with beta cyclodextrin complexes than solid dispersion (PVPK25) and Urea. Among all the formulations, VA3 drug-beta-cyclodextrin ratio was found to be better. The result confirmed that beta-cyclodextrin (BCD) showed better solubility and dissolution characteristics when compared to polyvinylpyrrolidone K-25 (PVP K25) and Urea.
Authors and Affiliations
Vijay Kumar , JS Venkatesh , MM Shankaraiah , Aman Kant , C Nagesh
Keywords
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