In-silicoimmunomodulator activity of photochemical from Zingiberofficinale R., Solanumlycopersicum L, and Ocimumtenuiflorum L. against Breast cancer
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 4
Abstract
Breast cancer is the most common type of cancer causing death in women globally. It is highly metastatic and can spread to various parts of body. There are many studies regarding role of cytokines in development of cancer. The cytokine NF-κB plays a major role in development and proliferation of cancer cells. Along with it TNF-alpha plays a dual role. According to its presence it can be tumour promoter and on the other hand it can be a cancer killer. The property of TNF in inducing cancer cell death renders it a potential cancer therapeutic, although much work is needed to reduce its toxicity for systematic TNF administration. Current treatments that are available for cancer are costly and have many side-effects. The main aim of this research was to determine in-silicoimmunomodulatory effects of various phytochemicals that are derived from Zingiberofficinale R. (ginger), Solanumlycopersicum L. (tomato), andOcimumtenuiflorum L. (holy basil)against the NF-κB and TNF-alpha. As, phytochemicals are naturally derived compounds they may have lesser or no side-effects and are available in low costs. The 3D structure of target protein receptor (cytokines) and phytochemicals (ligand) were retrieved from PDB and PubChem respectively. Out of twenty-three phytochemicals, fourteen satisfied Lipinski’s properties and were docked with NF-κB and TNF-alpha target proteins, using AutoDockVina 1.5.6. Roasmarinic-acid and Luteolin which are active phytochemicals from Ocimumtenuiflorum L. showed highest dock-score value with both target protein respectively. The outcome of the results can be further validated, using in-vitro immunomodulatory studies.
Authors and Affiliations
Priyanka B. Hegde, Lalit R. Samant
Keywords
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- EP ID EP415125
- DOI 10.9790/264X-0404014752.
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