In-Vitro Release Study of Paracetamol Using Carboxy Methyl Guar Gum as Binder
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 6
Abstract
The objective of the study was to develop the sustained release tablets of paracetamol, using carboxymethyl guar gum as a drug binder. Experimental approach: Tablets were prepared by wet granulation method. Granules were evaluated for loose bulk density (LBD), tapped bulk density (TBD) and compressibility index. Prepared tablet were evaluated for friability, hardness, uniformity of drug content and In-vitro release study. In-vitro release study was carried out by using USP type II apparatus in phosphate buffer (pH 6.8). Conclusion: Three different types of formulation were formulated (F1, F2, F3). F1 shows best result of 93.43% drug release over a time period of 12hrs amongst all the formulations.
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